Gene Therapy and Virotherapy of Gliomas

Julius W. Kim; Alan L. Chang; J. Robert Kane; Jacob S. Young; Jian Qiao; MacIej S. Lesniak

doi:10.1159/000469685

Gene Therapy and Virotherapy of Gliomas

Julius W. Kim, Alan L. Chang, J. Robert Kane, Jacob S. Young, Jian Qiao, MacIej S. Lesniak

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant brain tumors due to recent progress in understanding of the underlying cancer biology as well as improved techniques for genetic modification of potential therapeutics.

Original language	English (US)
Pages (from-to)	112-123
Number of pages	12
Journal	Progress in Neurological Surgery
Volume	32
DOIs	https://doi.org/10.1159/000469685
State	Published - 2018

ASJC Scopus subject areas

Surgery
Clinical Neurology

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title = "Gene Therapy and Virotherapy of Gliomas",

abstract = "Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant brain tumors due to recent progress in understanding of the underlying cancer biology as well as improved techniques for genetic modification of potential therapeutics.",

author = "Kim, {Julius W.} and Chang, {Alan L.} and Kane, {J. Robert} and Young, {Jacob S.} and Jian Qiao and Lesniak, {MacIej S.}",

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AU - Kim, Julius W.

AU - Chang, Alan L.

AU - Kane, J. Robert

AU - Young, Jacob S.

AU - Qiao, Jian

AU - Lesniak, MacIej S.

PY - 2018

Y1 - 2018

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AB - Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant brain tumors due to recent progress in understanding of the underlying cancer biology as well as improved techniques for genetic modification of potential therapeutics.

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Gene Therapy and Virotherapy of Gliomas

Abstract

ASJC Scopus subject areas

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