Gene Therapy and Virotherapy of Gliomas

Julius W. Kim, Alan L. Chang, J. Robert Kane, Jacob S. Young, Jian Qiao, MacIej S. Lesniak

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant brain tumors due to recent progress in understanding of the underlying cancer biology as well as improved techniques for genetic modification of potential therapeutics.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalProgress in neurological surgery
Volume32
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Kim, J. W., Chang, A. L., Kane, J. R., Young, J. S., Qiao, J., & Lesniak, M. S. (2018). Gene Therapy and Virotherapy of Gliomas. Progress in neurological surgery, 32, 112-123. https://doi.org/10.1159/000469685