Gene transfer into brain parenchyma elicits antitumor effects

Hassan M. Fathallah-Shaykh, Abdallah I. Kafrouni, Li Juan Zhao, George M. Smith, James Forman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Gene therapy strategies for cancer currently aim at targeting gene delivery to the malignant cell. In a mouse model of intracerebral Lewis lung carcinoma (3LL), adenoviral vectors transduce not only 3LL cells but also brain parenchymal cells including endothelial cells, neurons, microglia, and astrocytes~ in vivo~. Furthermore, transgene expression persists longer in brain than in tumor. Transfer of IFN-γ into brain parenchymal cells rather than tumor is both necessary and sufficient to generate antitumor therapeutic benefits. Therefore, parenchymal cells represent an effective and necessary target for delivery of genes that render the brain uninhabitable by the tumor.

Original languageEnglish (US)
Pages (from-to)1797-1799
Number of pages3
JournalCancer research
Volume60
Issue number7
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Fathallah-Shaykh, H. M., Kafrouni, A. I., Zhao, L. J., Smith, G. M., & Forman, J. (2000). Gene transfer into brain parenchyma elicits antitumor effects. Cancer research, 60(7), 1797-1799.