Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector

Drake Laface, Paul Hermonat, Edward Wakeland, Ammon Peck

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We describe here the transduction of murine hematopoietic progenitor cells with the dominant selectable neomycin drug-resistance (Neo) gene using a recombinant adeno-associated virus (AAV) vector. Successful transformation of progenitor cells to drug resistance was determined to be approximately 1.5% by colony formation in the presence of geneticin sulfate (G-418). The value of AAV as an alternative to the retrovirus vector systems is discussed.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalVirology
Volume162
Issue number2
DOIs
StatePublished - Feb 1988

ASJC Scopus subject areas

  • Virology

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