General and efficient copper-catalyzed three-component coupling reaction towards imidazoheterocycles: One-pot synthesis of alpidem and zolpidem

Natalia Chernyak, Vladimir Gevorgyan

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

(Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme).

Original languageEnglish (US)
Pages (from-to)2743-2746
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number15
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Fingerprint

Copper
Pharmaceutical Preparations
zolpidem
alpidem

Keywords

  • Cyclization
  • Heterocycles
  • Homogeneous catalysis
  • Imidazopyridines
  • Multicomponent reactions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

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KW - Homogeneous catalysis

KW - Imidazopyridines

KW - Multicomponent reactions

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