General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Yang Wang, Anton V. Gulevich, Vladimir Gevorgyan

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme).

Original languageEnglish (US)
Pages (from-to)15836-15840
Number of pages5
JournalChemistry - A European Journal
Volume19
Issue number47
DOIs
StatePublished - Nov 18 2013
Externally publishedYes

Keywords

  • C-H activation
  • benzocoumarins
  • carboxylic acids
  • oxygenation
  • radical reactions

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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