General and practical one-pot synthesis of dihydrobenzosiloles from styrenes

Alexey Kuznetsov, Vladimir Gevorgyan

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

A one-pot synthesis of dihydrobenzosiloles from styrenes has been developed. The reaction involves the nickel-catalyzed hydrosilylation of styrene with diphenylsilane, followed by the iridium-catalyzed dehydrogenative cyclization. This method is efficient for both electron-rich and -deficient styrenes and exhibits good functional group tolerance, as well as excellent regioselectivity. The forming dihydrobenzosiloles can be efficiently converted into valuable benzosiloles or 2-hydroxyphenethyl alcohols.

Original languageEnglish (US)
Pages (from-to)914-917
Number of pages4
JournalOrganic Letters
Volume14
Issue number3
DOIs
StatePublished - Feb 3 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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