General and selective head-to-head dimerization of terminal alkynes proceeding via hydropalladation pathway

Claire Jahier, Olga V. Zatolochnaya, Nickolay V. Zvyagintsev, Valentine P. Ananikov, Vladimir Gevorgyan

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

A general highly regio- and stereoselective palladium-catalyzed head-to-head dimerization reaction of terminal acetylenes is presented. This methodology allows for the efficient synthesis of a variety of 1,4-enynes as single E stereoisomers. Computational studies reveal that this dimerization reaction proceeds via the hydropalladation pathway.

Original languageEnglish (US)
Pages (from-to)2846-2849
Number of pages4
JournalOrganic Letters
Volume14
Issue number11
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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