General anesthesia suppresses normal heart rate variability in humans

Gerald Matchett, Philip Wood

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The human heart normally exhibits robust beat-to-beat heart rate variability (HRV). The loss of this variability is associated with pathology, including disease states such as congestive heart failure (CHF). The effect of general anesthesia on intrinsic HRV is unknown. In this prospective, observational study we enrolled 100 human subjects having elective major surgical procedures under general anesthesia. We recorded continuous heart rate data via continuous electrocardiogram before, during, and after anesthesia, and we assessed HRV of the R-R intervals. We assessed HRV using several common metrics including Detrended Fluctuation Analysis (DFA), Multifractal Analysis, and Multiscale Entropy Analysis. Each of these analyses was done in each of the four clinical phases for each study subject over the course of 24 h: Before anesthesia, during anesthesia, early recovery, and late recovery. On average, we observed a loss of variability on the aforementioned metrics that appeared to correspond to the state of general anesthesia. Following the conclusion of anesthesia, most study subjects appeared to regain their normal HRV, although this did not occur immediately. The resumption of normal HRV was especially delayed on DFA. Qualitatively, the reduction in HRV under anesthesia appears similar to the reduction in HRV observed in CHF. These observations will need to be validated in future studies, and the broader clinical implications of these observations, if any, are unknown.

Original languageEnglish (US)
Pages (from-to)23129
Number of pages1
JournalChaos (Woodbury, N.Y.)
Volume24
Issue number2
DOIs
StatePublished - Jun 1 2014

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anesthesia
Heart Rate Variability
General Anesthesia
heart rate
Heart Rate
Anesthesia
Congestive Heart Failure
Beat
Recovery
Fluctuations
Heart Failure
synchronism
Elective Surgical Procedures
Metric
Unknown
Multifractal Analysis
Observational Study
recovery
Human
electrocardiography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

General anesthesia suppresses normal heart rate variability in humans. / Matchett, Gerald; Wood, Philip.

In: Chaos (Woodbury, N.Y.), Vol. 24, No. 2, 01.06.2014, p. 23129.

Research output: Contribution to journalArticle

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