General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation

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38 Scopus citations

Abstract

A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential C-H functionalization processes.

Original languageEnglish (US)
Pages (from-to)2255-2259
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number7
DOIs
StatePublished - Feb 9 2015
Externally publishedYes

Keywords

  • C-H activation
  • Carboxylation
  • Palladium
  • Phenols
  • Salicylic acids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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