Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene

Jean Ann Maguire; Alyssa L. Gagne; Pedro Gonzalez-Alegre; Beverly L. Davidson; Vikram Shakkottai; Paul Gadue; Deborah L. French

doi:10.1016/j.scr.2018.101361

Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene

Jean Ann Maguire, Alyssa L. Gagne, Pedro Gonzalez-Alegre, Beverly L. Davidson, Vikram Shakkottai, Paul Gadue, Deborah L. French

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12 Scopus citations

Abstract

Spinocerebellar Ataxia Type 2 (SCA2) is an autosomal dominant disease characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. SCA2 is caused by spontaneous misfolding and aggregate formation from abnormal CAG trinucleotide repeat expansion in the coding region of the ATXN2 gene. Here we describe the generation of two distinct iPSC lines from patients with SCA2.

Original language	English (US)
Article number	101361
Journal	Stem Cell Research
Volume	34
DOIs	https://doi.org/10.1016/j.scr.2018.101361
State	Published - Jan 2019
Externally published	Yes

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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Maguire, J. A., Gagne, A. L., Gonzalez-Alegre, P., Davidson, B. L., Shakkottai, V., Gadue, P., & French, D. L. (2019). Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. Stem Cell Research, 34, Article 101361. https://doi.org/10.1016/j.scr.2018.101361

Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. / Maguire, Jean Ann; Gagne, Alyssa L.; Gonzalez-Alegre, Pedro et al.
In: Stem Cell Research, Vol. 34, 101361, 01.2019.

Research output: Contribution to journal › Article › peer-review

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abstract = "Spinocerebellar Ataxia Type 2 (SCA2) is an autosomal dominant disease characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. SCA2 is caused by spontaneous misfolding and aggregate formation from abnormal CAG trinucleotide repeat expansion in the coding region of the ATXN2 gene. Here we describe the generation of two distinct iPSC lines from patients with SCA2.",

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AB - Spinocerebellar Ataxia Type 2 (SCA2) is an autosomal dominant disease characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. SCA2 is caused by spontaneous misfolding and aggregate formation from abnormal CAG trinucleotide repeat expansion in the coding region of the ATXN2 gene. Here we describe the generation of two distinct iPSC lines from patients with SCA2.

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Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene

Abstract

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