Generation of ultra-small PLGA nanoparticles by sequential centrifugation

Xingwang Wu, Jiangbing Zhou, Toral R. Patel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Direct, local delivery of polymer nanoparticles to the brain is a promising strategy to bypass the blood-brain barrier (BBB) and safely deliver a large therapeutic payload. However, even with the aid of convection-enhanced delivery (CED) techniques, this approach has been limited by the inability to fabricate appropriately sized polymer nanoparticles. Here, we outline a versatile and efficient method for producing polymer nanoparticles that are <100 nm in diameter and can be delivered to the brain via CED.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages17-24
Number of pages8
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1831
ISSN (Print)1064-3745

Fingerprint

Centrifugation
Nanoparticles
Convection
Polymers
Brain
Blood-Brain Barrier
polylactic acid-polyglycolic acid copolymer
Therapeutics

Keywords

  • Blood-brain barrier
  • Brain
  • Convection-enhanced delivery
  • Nanoparticle
  • PLGA
  • Polymer

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Wu, X., Zhou, J., & Patel, T. R. (2018). Generation of ultra-small PLGA nanoparticles by sequential centrifugation. In Methods in Molecular Biology (pp. 17-24). (Methods in Molecular Biology; Vol. 1831). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8661-3_2

Generation of ultra-small PLGA nanoparticles by sequential centrifugation. / Wu, Xingwang; Zhou, Jiangbing; Patel, Toral R.

Methods in Molecular Biology. Humana Press Inc., 2018. p. 17-24 (Methods in Molecular Biology; Vol. 1831).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wu, X, Zhou, J & Patel, TR 2018, Generation of ultra-small PLGA nanoparticles by sequential centrifugation. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1831, Humana Press Inc., pp. 17-24. https://doi.org/10.1007/978-1-4939-8661-3_2
Wu X, Zhou J, Patel TR. Generation of ultra-small PLGA nanoparticles by sequential centrifugation. In Methods in Molecular Biology. Humana Press Inc. 2018. p. 17-24. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8661-3_2
Wu, Xingwang ; Zhou, Jiangbing ; Patel, Toral R. / Generation of ultra-small PLGA nanoparticles by sequential centrifugation. Methods in Molecular Biology. Humana Press Inc., 2018. pp. 17-24 (Methods in Molecular Biology).
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