Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment, Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang, Cindy Bryant, Christopher Cassady, Carmen Garcia, Yvette R. Johnson, Heidi E. Karpen, Martha M. Munden, Geneva ShoresJohn Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Henrietta Bada, Harigovinda R. Challa, Deborah L. Grider, Vesna Kriss, Vicki Whitehead, George Abdenour, Charles Bauer, Gary Danton, Daniel Montesinos, Saigal Gaurav, Willy Philias, Uygar Teomete, John Barks, Mary Christensen, Ramon Sanchez, Makayla Sieg, Stephanie Wiggins, Janell Fuller, Carol Hartenberger, Rebecca Montman, Jessica B. Williams, Susan Williamson, Carl Bose, Cynthia L. Clark, Matthew Laughon, Soraya Abbasi, Noah M. Cook, Toni Mancini, Aasma Chaudhary, Christopher DeMauro, Barbara Schmidt, Ellen Dean, Fabien Eyal, Paul Maertens, Thomas F. Boulden, Harris L. Cohen, Shelia Dempsey, Pam LeNoue, Massroor Pourcyrous, Karie Bird, Roger G. Faix, Gary Hedlund, Kevin Moore, Karen Osborne, Kimberlee Weaver-Lewis, Bradley A. Yoder, Dennis E. Mayock, Manjiri Dighe, Patricia L. Brown, T. Michael O'Shea, Nancy Peters, Terrie Inder, Karen Lukas, Amit Mathur, Robert McKinstry, Joshua Shimony, Aparna Joshi, Jay Ann Nelson, Seetha Shankaran, Eunice H. Woldt, Kenneth Baker, Matthew J. Bizzarro, Murim Choi, Richard Ehrenkranz, Anita Farhi, T. R. Goodman, Karol Katz, Monica Konstantino, Zhifa Liu, Jill Maller-Kesselman, Carol Nelson-Williams, Xiaoyi Min, Michele C. Walsh, Avroy A. Fanaroff, Nancy S. Newman, Bonnie S. Siner, Kurt Schibler, Edward F. Donovan, Vivek Narendran, Barbara Alexander, Cathy Grisby, Jody Hessling, Marcia Worley Mersmann, Holly L. Mincey, C. Michael Cotten, Ronald N. Goldberg, Kathy J. Auten, Barbara J. Stoll, Ellen C. Hale, Rosemary D. Higgins, Linda L. Wright, Sumner J. Yaffe, Elizabeth M. McClure, Stephanie Wilson Archer, Abhik Das, Scott A. McDonald, W. Kenneth Poole, Betty K. Hastings, Jeanette O'Donnell Auman, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, David K. Stevenson, M. Bethany Ball, Namasivayam Ambalavanan, Monica V. Collins, Shirley S. Cosby, Neil N. Finer, Maynard R. Rasmussen, David Kaegi, Kathy Arnell, Clarence Demetrio, Wade Rich, Edward F. Bell, Karen J. Johnson, Jeffrey C. Murray, Shahnaz Duara, Ruth Everett-Thomas, Sheldon B. Korones, Tina Hudson, Pablo J. Sánchez, Abbot R. Laptook, Walid A. Salhab, Susie Madison, Nancy A. Miller, Gaynelle Hensley, Alicia Guzman, Kathleen A. Kennedy, Jon E. Tyson, Esther G. Akpa, Patty A. Cluff, Claudia I. Franco, Anna E. Lis, Georgia E. McDavid, Patti Pierce Tate, Beena G. Sood, G. Ganesh Konduri, Rebecca Bara, Geraldine Muran, Alan H. Jobe

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original languageEnglish (US)
Pages (from-to)592-603
Number of pages12
JournalSeminars in Perinatology
Volume39
Issue number8
DOIs
StatePublished - Dec 2015

Keywords

  • GWAS
  • Genes
  • Intraventricular hemorrhage
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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