Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment; Ulrika Ådén; Charles R. Bauer; Henrietta S. Bada; Waldemar A. Carlo; Jeffrey R. Kaiser; Aiping Lin; Charles Michael Cotten; Jeffrey Murray; Grier Page; Mikko Hallman; Richard P. Lifton; Heping Zhang; Cindy Bryant; Christopher Cassady; Carmen Garcia; Yvette R. Johnson; Heidi E. Karpen; Martha M. Munden; Geneva Shores; John Cassese; Angelita M. Hensman; Elisa Vieira; Betty Vohr; Michael Wallach; James J. Cummings; Scott S. MacGilvray; Sherry Moseley; Vickie Trapanotto; Brenda Poindexter; Leslie Dawn Wilson; Shirley Wright-Coltart; Marco Bartocci; Gordana Printz; Andrew Hopper; Leon Smith; Beverly P. Wood; Lionel Young; Walter C. Allan; Jessica Alfsson; Karin Sävman; Stuart A. Royal; Daniel W. Young; Shirley Cosby; Crystal Helms; Teresita Angtuaco; N. Carol Sikes; Melanie J. Mason; R. Whit Hall; Henrietta Bada; Harigovinda R. Challa; Deborah L. Grider; Vesna Kriss; Vicki Whitehead; George Abdenour; Charles Bauer; Gary Danton; Daniel Montesinos; Saigal Gaurav; Willy Philias; Uygar Teomete; John Barks; Mary Christensen; Ramon Sanchez; Makayla Sieg; Stephanie Wiggins; Janell Fuller; Carol Hartenberger; Rebecca Montman; Jessica B. Williams; Susan Williamson; Carl Bose; Cynthia L. Clark; Matthew Laughon; Soraya Abbasi; Noah M. Cook; Toni Mancini; Aasma Chaudhary; Christopher DeMauro; Barbara Schmidt; Ellen Dean; Fabien Eyal; Paul Maertens; Thomas F. Boulden; Harris L. Cohen; Shelia Dempsey; Pam LeNoue; Massroor Pourcyrous; Karie Bird; Roger G. Faix; Gary Hedlund; Kevin Moore; Karen Osborne; Kimberlee Weaver-Lewis; Bradley A. Yoder; Dennis E. Mayock; Manjiri Dighe; Patricia L. Brown; T. Michael O'Shea; Nancy Peters; Terrie Inder; Karen Lukas; Amit Mathur; Robert McKinstry; Joshua Shimony; Aparna Joshi; Jay Ann Nelson; Seetha Shankaran; Eunice H. Woldt; Kenneth Baker; Matthew J. Bizzarro; Murim Choi; Richard Ehrenkranz; Anita Farhi; T. R. Goodman; Karol Katz; Monica Konstantino; Zhifa Liu; Jill Maller-Kesselman; Carol Nelson-Williams; Xiaoyi Min; Michele C. Walsh; Avroy A. Fanaroff; Nancy S. Newman; Bonnie S. Siner; Kurt Schibler; Edward F. Donovan; Vivek Narendran; Barbara Alexander; Cathy Grisby; Jody Hessling; Marcia Worley Mersmann; Holly L. Mincey; C. Michael Cotten; Ronald N. Goldberg; Kathy J. Auten; Barbara J. Stoll; Ellen C. Hale; Rosemary D. Higgins; Linda L. Wright; Sumner J. Yaffe; Elizabeth M. McClure; Stephanie Wilson Archer; Abhik Das; Scott A. McDonald; W. Kenneth Poole; Betty K. Hastings; Jeanette O'Donnell Auman; Kristin M. Zaterka-Baxter; Krisa P. Van Meurs; David K. Stevenson; M. Bethany Ball; Namasivayam Ambalavanan; Monica V. Collins; Shirley S. Cosby; Neil N. Finer; Maynard R. Rasmussen; David Kaegi; Kathy Arnell; Clarence Demetrio; Wade Rich; Edward F. Bell; Karen J. Johnson; Jeffrey C. Murray; Shahnaz Duara; Ruth Everett-Thomas; Sheldon B. Korones; Tina Hudson; Pablo J. Sánchez; Abbot R. Laptook; Walid A. Salhab; Susie Madison; Nancy A. Miller; Gaynelle Hensley; Alicia Guzman; Kathleen A. Kennedy; Jon E. Tyson; Esther G. Akpa; Patty A. Cluff; Claudia I. Franco; Anna E. Lis; Georgia E. McDavid; Patti Pierce Tate; Beena G. Sood; G. Ganesh Konduri; Rebecca Bara; Geraldine Muran; Alan H. Jobe

doi:10.1053/j.semperi.2015.09.006

Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment, Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang, Cindy Bryant, Christopher Cassady, Carmen Garcia, Yvette R. Johnson, Heidi E. Karpen, Martha M. Munden, Geneva ShoresJohn Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Henrietta Bada, Harigovinda R. Challa, Deborah L. Grider, Vesna Kriss, Vicki Whitehead, George Abdenour, Charles Bauer, Gary Danton, Daniel Montesinos, Saigal Gaurav, Willy Philias, Uygar Teomete, John Barks, Mary Christensen, Ramon Sanchez, Makayla Sieg, Stephanie Wiggins, Janell Fuller, Carol Hartenberger, Rebecca Montman, Jessica B. Williams, Susan Williamson, Carl Bose, Cynthia L. Clark, Matthew Laughon, Soraya Abbasi, Noah M. Cook, Toni Mancini, Aasma Chaudhary, Christopher DeMauro, Barbara Schmidt, Ellen Dean, Fabien Eyal, Paul Maertens, Thomas F. Boulden, Harris L. Cohen, Shelia Dempsey, Pam LeNoue, Massroor Pourcyrous, Karie Bird, Roger G. Faix, Gary Hedlund, Kevin Moore, Karen Osborne, Kimberlee Weaver-Lewis, Bradley A. Yoder, Dennis E. Mayock, Manjiri Dighe, Patricia L. Brown, T. Michael O'Shea, Nancy Peters, Terrie Inder, Karen Lukas, Amit Mathur, Robert McKinstry, Joshua Shimony, Aparna Joshi, Jay Ann Nelson, Seetha Shankaran, Eunice H. Woldt, Kenneth Baker, Matthew J. Bizzarro, Murim Choi, Richard Ehrenkranz, Anita Farhi, T. R. Goodman, Karol Katz, Monica Konstantino, Zhifa Liu, Jill Maller-Kesselman, Carol Nelson-Williams, Xiaoyi Min, Michele C. Walsh, Avroy A. Fanaroff, Nancy S. Newman, Bonnie S. Siner, Kurt Schibler, Edward F. Donovan, Vivek Narendran, Barbara Alexander, Cathy Grisby, Jody Hessling, Marcia Worley Mersmann, Holly L. Mincey, C. Michael Cotten, Ronald N. Goldberg, Kathy J. Auten, Barbara J. Stoll, Ellen C. Hale, Rosemary D. Higgins, Linda L. Wright, Sumner J. Yaffe, Elizabeth M. McClure, Stephanie Wilson Archer, Abhik Das, Scott A. McDonald, W. Kenneth Poole, Betty K. Hastings, Jeanette O'Donnell Auman, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, David K. Stevenson, M. Bethany Ball, Namasivayam Ambalavanan, Monica V. Collins, Shirley S. Cosby, Neil N. Finer, Maynard R. Rasmussen, David Kaegi, Kathy Arnell, Clarence Demetrio, Wade Rich, Edward F. Bell, Karen J. Johnson, Jeffrey C. Murray, Shahnaz Duara, Ruth Everett-Thomas, Sheldon B. Korones, Tina Hudson, Pablo J. Sánchez, Abbot R. Laptook, Walid A. Salhab, Susie Madison, Nancy A. Miller, Gaynelle Hensley, Alicia Guzman, Kathleen A. Kennedy, Jon E. Tyson, Esther G. Akpa, Patty A. Cluff, Claudia I. Franco, Anna E. Lis, Georgia E. McDavid, Patti Pierce Tate, Beena G. Sood, G. Ganesh Konduri, Rebecca Bara, Geraldine Muran, Alan H. Jobe

Pediatrics

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original language	English (US)
Pages (from-to)	592-603
Number of pages	12
Journal	Seminars in Perinatology
Volume	39
Issue number	8
DOIs	https://doi.org/10.1053/j.semperi.2015.09.006
State	Published - Dec 2015

Keywords

GWAS
Genes
Intraventricular hemorrhage
Neonate
Preterm

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1053/j.semperi.2015.09.006

Cite this

Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., Lin, A., Cotten, C. M., Murray, J., Page, G., Hallman, M., Lifton, R. P., Zhang, H., Bryant, C., Cassady, C., Garcia, C., Johnson, Y. R., Karpen, H. E., Munden, M. M., ... Jobe, A. H. (2015). Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology, 39(8), 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

Ment, LR, Ådén, U, Bauer, CR, Bada, HS, Carlo, WA, Kaiser, JR, Lin, A, Cotten, CM, Murray, J, Page, G, Hallman, M, Lifton, RP, Zhang, H, Bryant, C, Cassady, C, Garcia, C, Johnson, YR, Karpen, HE, Munden, MM, Shores, G, Cassese, J, Hensman, AM, Vieira, E, Vohr, B, Wallach, M, Cummings, JJ, MacGilvray, SS, Moseley, S, Trapanotto, V, Poindexter, B, Wilson, LD, Wright-Coltart, S, Bartocci, M, Printz, G, Hopper, A, Smith, L, Wood, BP, Young, L, Allan, WC, Alfsson, J, Sävman, K, Royal, SA, Young, DW, Cosby, S, Helms, C, Angtuaco, T, Carol Sikes, N, Mason, MJ, Whit Hall, R, Bada, H, Challa, HR, Grider, DL, Kriss, V, Whitehead, V, Abdenour, G, Bauer, C, Danton, G, Montesinos, D, Gaurav, S, Philias, W, Teomete, U, Barks, J, Christensen, M, Sanchez, R, Sieg, M, Wiggins, S, Fuller, J, Hartenberger, C, Montman, R, Williams, JB, Williamson, S, Bose, C, Clark, CL, Laughon, M, Abbasi, S, Cook, NM, Mancini, T, Chaudhary, A, DeMauro, C, Schmidt, B, Dean, E, Eyal, F, Maertens, P, Boulden, TF, Cohen, HL, Dempsey, S, LeNoue, P, Pourcyrous, M, Bird, K, Faix, RG, Hedlund, G, Moore, K, Osborne, K, Weaver-Lewis, K, Yoder, BA, Mayock, DE, Dighe, M, Brown, PL, Michael O'Shea, T, Peters, N, Inder, T, Lukas, K, Mathur, A, McKinstry, R, Shimony, J, Joshi, A, Ann Nelson, J, Shankaran, S, Woldt, EH, Baker, K, Bizzarro, MJ, Choi, M, Ehrenkranz, R, Farhi, A, Goodman, TR, Katz, K, Konstantino, M, Liu, Z, Maller-Kesselman, J, Nelson-Williams, C, Min, X, Walsh, MC, Fanaroff, AA, Newman, NS, Siner, BS, Schibler, K, Donovan, EF, Narendran, V, Alexander, B, Grisby, C, Hessling, J, Mersmann, MW, Mincey, HL, Michael Cotten, C, Goldberg, RN, Auten, KJ, Stoll, BJ, Hale, EC, Higgins, RD, Wright, LL, Yaffe, SJ, McClure, EM, Archer, SW, Das, A, McDonald, SA, Poole, WK, Hastings, BK, O'Donnell Auman, J, Zaterka-Baxter, KM, Van Meurs, KP, Stevenson, DK, Ball, MB, Ambalavanan, N, Collins, MV, Cosby, SS, Finer, NN, Rasmussen, MR, Kaegi, D, Arnell, K, Demetrio, C, Rich, W, Bell, EF, Johnson, KJ, Murray, JC, Duara, S, Everett-Thomas, R, Korones, SB, Hudson, T, Sánchez, PJ, Laptook, AR, Salhab, WA, Madison, S, Miller, NA, Hensley, G, Guzman, A, Kennedy, KA, Tyson, JE, Akpa, EG, Cluff, PA, Franco, CI, Lis, AE, McDavid, GE, Tate, PP, Sood, BG, Ganesh Konduri, G, Bara, R, Muran, G & Jobe, AH 2015, 'Genes and environment in neonatal intraventricular hemorrhage', Seminars in Perinatology, vol. 39, no. 8, pp. 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

@article{ded0c0eb30c9439d913c0950478dba33,

title = "Genes and environment in neonatal intraventricular hemorrhage",

abstract = "Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.",

keywords = "GWAS, Genes, Intraventricular hemorrhage, Neonate, Preterm",

author = "Ment, {Laura R.} and Ulrika {\AA}d{\'e}n and Bauer, {Charles R.} and Bada, {Henrietta S.} and Carlo, {Waldemar A.} and Kaiser, {Jeffrey R.} and Aiping Lin and Cotten, {Charles Michael} and Jeffrey Murray and Grier Page and Mikko Hallman and Lifton, {Richard P.} and Heping Zhang and Cindy Bryant and Christopher Cassady and Carmen Garcia and Johnson, {Yvette R.} and Karpen, {Heidi E.} and Munden, {Martha M.} and Geneva Shores and John Cassese and Hensman, {Angelita M.} and Elisa Vieira and Betty Vohr and Michael Wallach and Cummings, {James J.} and MacGilvray, {Scott S.} and Sherry Moseley and Vickie Trapanotto and Brenda Poindexter and Wilson, {Leslie Dawn} and Shirley Wright-Coltart and Marco Bartocci and Gordana Printz and Andrew Hopper and Leon Smith and Wood, {Beverly P.} and Lionel Young and Allan, {Walter C.} and Jessica Alfsson and Karin S{\"a}vman and Royal, {Stuart A.} and Young, {Daniel W.} and Shirley Cosby and Crystal Helms and Teresita Angtuaco and {Carol Sikes}, N. and Mason, {Melanie J.} and {Whit Hall}, R. and Henrietta Bada and Challa, {Harigovinda R.} and Grider, {Deborah L.} and Vesna Kriss and Vicki Whitehead and George Abdenour and Charles Bauer and Gary Danton and Daniel Montesinos and Saigal Gaurav and Willy Philias and Uygar Teomete and John Barks and Mary Christensen and Ramon Sanchez and Makayla Sieg and Stephanie Wiggins and Janell Fuller and Carol Hartenberger and Rebecca Montman and Williams, {Jessica B.} and Susan Williamson and Carl Bose and Clark, {Cynthia L.} and Matthew Laughon and Soraya Abbasi and Cook, {Noah M.} and Toni Mancini and Aasma Chaudhary and Christopher DeMauro and Barbara Schmidt and Ellen Dean and Fabien Eyal and Paul Maertens and Boulden, {Thomas F.} and Cohen, {Harris L.} and Shelia Dempsey and Pam LeNoue and Massroor Pourcyrous and Karie Bird and Faix, {Roger G.} and Gary Hedlund and Kevin Moore and Karen Osborne and Kimberlee Weaver-Lewis and Yoder, {Bradley A.} and Mayock, {Dennis E.} and Manjiri Dighe and Brown, {Patricia L.} and {Michael O'Shea}, T. and Nancy Peters and Terrie Inder and Karen Lukas and Amit Mathur and Robert McKinstry and Joshua Shimony and Aparna Joshi and {Ann Nelson}, Jay and Seetha Shankaran and Woldt, {Eunice H.} and Kenneth Baker and Bizzarro, {Matthew J.} and Murim Choi and Richard Ehrenkranz and Anita Farhi and Goodman, {T. R.} and Karol Katz and Monica Konstantino and Zhifa Liu and Jill Maller-Kesselman and Carol Nelson-Williams and Xiaoyi Min and Walsh, {Michele C.} and Fanaroff, {Avroy A.} and Newman, {Nancy S.} and Siner, {Bonnie S.} and Kurt Schibler and Donovan, {Edward F.} and Vivek Narendran and Barbara Alexander and Cathy Grisby and Jody Hessling and Mersmann, {Marcia Worley} and Mincey, {Holly L.} and {Michael Cotten}, C. and Goldberg, {Ronald N.} and Auten, {Kathy J.} and Stoll, {Barbara J.} and Hale, {Ellen C.} and Higgins, {Rosemary D.} and Wright, {Linda L.} and Yaffe, {Sumner J.} and McClure, {Elizabeth M.} and Archer, {Stephanie Wilson} and Abhik Das and McDonald, {Scott A.} and Poole, {W. Kenneth} and Hastings, {Betty K.} and {O'Donnell Auman}, Jeanette and Zaterka-Baxter, {Kristin M.} and {Van Meurs}, {Krisa P.} and Stevenson, {David K.} and Ball, {M. Bethany} and Namasivayam Ambalavanan and Collins, {Monica V.} and Cosby, {Shirley S.} and Finer, {Neil N.} and Rasmussen, {Maynard R.} and David Kaegi and Kathy Arnell and Clarence Demetrio and Wade Rich and Bell, {Edward F.} and Johnson, {Karen J.} and Murray, {Jeffrey C.} and Shahnaz Duara and Ruth Everett-Thomas and Korones, {Sheldon B.} and Tina Hudson and S{\'a}nchez, {Pablo J.} and Laptook, {Abbot R.} and Salhab, {Walid A.} and Susie Madison and Miller, {Nancy A.} and Gaynelle Hensley and Alicia Guzman and Kennedy, {Kathleen A.} and Tyson, {Jon E.} and Akpa, {Esther G.} and Cluff, {Patty A.} and Franco, {Claudia I.} and Lis, {Anna E.} and McDavid, {Georgia E.} and Tate, {Patti Pierce} and Sood, {Beena G.} and {Ganesh Konduri}, G. and Rebecca Bara and Geraldine Muran and Jobe, {Alan H.}",

note = "Funding Information: The Gene Targets for IVH Study Group was supported by NIH NS053865. Dr. Zhang was partially supported by NIH R01 DA016750-09. Funding Information: The National Institutes of Health, United States (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR24979 ) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States (Grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, and U10 HD53109 ) provided grant support for the Neonatal Research Networkʼs Genomics Study. In addition, Dr. Murray received assistance for the GENEVA study from the National Human Genome Research Institute, United States ( U01 HG4423 ) and Dr. Aden received support from Swedish Medical Research Council ( 523-2011-3981, 2009-4250, and 523-2009-7054 ), the regional agreement on medical training and clinical research (ALF 20140316) between Stockholm County Council and the Karolinska Institutet, the Marianne and Marcus Wallenberg foundation ( MMW 2011.0085 ), and the Swedish Brain Foundation ( FP2014-0135 ). The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = dec,

doi = "10.1053/j.semperi.2015.09.006",

language = "English (US)",

volume = "39",

pages = "592--603",

journal = "Seminars in Perinatology",

issn = "0146-0005",

publisher = "W.B. Saunders Ltd",

number = "8",

}

TY - JOUR

T1 - Genes and environment in neonatal intraventricular hemorrhage

AU - Ment, Laura R.

AU - Ådén, Ulrika

AU - Bauer, Charles R.

AU - Bada, Henrietta S.

AU - Carlo, Waldemar A.

AU - Kaiser, Jeffrey R.

AU - Lin, Aiping

AU - Cotten, Charles Michael

AU - Murray, Jeffrey

AU - Page, Grier

AU - Hallman, Mikko

AU - Lifton, Richard P.

AU - Zhang, Heping

AU - Bryant, Cindy

AU - Cassady, Christopher

AU - Garcia, Carmen

AU - Johnson, Yvette R.

AU - Karpen, Heidi E.

AU - Munden, Martha M.

AU - Shores, Geneva

AU - Cassese, John

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Vohr, Betty

AU - Wallach, Michael

AU - Cummings, James J.

AU - MacGilvray, Scott S.

AU - Moseley, Sherry

AU - Trapanotto, Vickie

AU - Poindexter, Brenda

AU - Wilson, Leslie Dawn

AU - Wright-Coltart, Shirley

AU - Bartocci, Marco

AU - Printz, Gordana

AU - Hopper, Andrew

AU - Smith, Leon

AU - Wood, Beverly P.

AU - Young, Lionel

AU - Allan, Walter C.

AU - Alfsson, Jessica

AU - Sävman, Karin

AU - Royal, Stuart A.

AU - Young, Daniel W.

AU - Cosby, Shirley

AU - Helms, Crystal

AU - Angtuaco, Teresita

AU - Carol Sikes, N.

AU - Mason, Melanie J.

AU - Whit Hall, R.

AU - Bada, Henrietta

AU - Challa, Harigovinda R.

AU - Grider, Deborah L.

AU - Kriss, Vesna

AU - Whitehead, Vicki

AU - Abdenour, George

AU - Bauer, Charles

AU - Danton, Gary

AU - Montesinos, Daniel

AU - Gaurav, Saigal

AU - Philias, Willy

AU - Teomete, Uygar

AU - Barks, John

AU - Christensen, Mary

AU - Sanchez, Ramon

AU - Sieg, Makayla

AU - Wiggins, Stephanie

AU - Fuller, Janell

AU - Hartenberger, Carol

AU - Montman, Rebecca

AU - Williams, Jessica B.

AU - Williamson, Susan

AU - Bose, Carl

AU - Clark, Cynthia L.

AU - Laughon, Matthew

AU - Abbasi, Soraya

AU - Cook, Noah M.

AU - Mancini, Toni

AU - Chaudhary, Aasma

AU - DeMauro, Christopher

AU - Schmidt, Barbara

AU - Dean, Ellen

AU - Eyal, Fabien

AU - Maertens, Paul

AU - Boulden, Thomas F.

AU - Cohen, Harris L.

AU - Dempsey, Shelia

AU - LeNoue, Pam

AU - Pourcyrous, Massroor

AU - Bird, Karie

AU - Faix, Roger G.

AU - Hedlund, Gary

AU - Moore, Kevin

AU - Osborne, Karen

AU - Weaver-Lewis, Kimberlee

AU - Yoder, Bradley A.

AU - Mayock, Dennis E.

AU - Dighe, Manjiri

AU - Brown, Patricia L.

AU - Michael O'Shea, T.

AU - Peters, Nancy

AU - Inder, Terrie

AU - Lukas, Karen

AU - Mathur, Amit

AU - McKinstry, Robert

AU - Shimony, Joshua

AU - Joshi, Aparna

AU - Ann Nelson, Jay

AU - Shankaran, Seetha

AU - Woldt, Eunice H.

AU - Baker, Kenneth

AU - Bizzarro, Matthew J.

AU - Choi, Murim

AU - Ehrenkranz, Richard

AU - Farhi, Anita

AU - Goodman, T. R.

AU - Katz, Karol

AU - Konstantino, Monica

AU - Liu, Zhifa

AU - Maller-Kesselman, Jill

AU - Nelson-Williams, Carol

AU - Min, Xiaoyi

AU - Walsh, Michele C.

AU - Fanaroff, Avroy A.

AU - Newman, Nancy S.

AU - Siner, Bonnie S.

AU - Schibler, Kurt

AU - Donovan, Edward F.

AU - Narendran, Vivek

AU - Alexander, Barbara

AU - Grisby, Cathy

AU - Hessling, Jody

AU - Mersmann, Marcia Worley

AU - Mincey, Holly L.

AU - Michael Cotten, C.

AU - Goldberg, Ronald N.

AU - Auten, Kathy J.

AU - Stoll, Barbara J.

AU - Hale, Ellen C.

AU - Higgins, Rosemary D.

AU - Wright, Linda L.

AU - Yaffe, Sumner J.

AU - McClure, Elizabeth M.

AU - Archer, Stephanie Wilson

AU - Das, Abhik

AU - McDonald, Scott A.

AU - Poole, W. Kenneth

AU - Hastings, Betty K.

AU - O'Donnell Auman, Jeanette

AU - Zaterka-Baxter, Kristin M.

AU - Van Meurs, Krisa P.

AU - Stevenson, David K.

AU - Ball, M. Bethany

AU - Ambalavanan, Namasivayam

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Finer, Neil N.

AU - Rasmussen, Maynard R.

AU - Kaegi, David

AU - Arnell, Kathy

AU - Demetrio, Clarence

AU - Rich, Wade

AU - Bell, Edward F.

AU - Johnson, Karen J.

AU - Murray, Jeffrey C.

AU - Duara, Shahnaz

AU - Everett-Thomas, Ruth

AU - Korones, Sheldon B.

AU - Hudson, Tina

AU - Sánchez, Pablo J.

AU - Laptook, Abbot R.

AU - Salhab, Walid A.

AU - Madison, Susie

AU - Miller, Nancy A.

AU - Hensley, Gaynelle

AU - Guzman, Alicia

AU - Kennedy, Kathleen A.

AU - Tyson, Jon E.

AU - Akpa, Esther G.

AU - Cluff, Patty A.

AU - Franco, Claudia I.

AU - Lis, Anna E.

AU - McDavid, Georgia E.

AU - Tate, Patti Pierce

AU - Sood, Beena G.

AU - Ganesh Konduri, G.

AU - Bara, Rebecca

AU - Muran, Geraldine

AU - Jobe, Alan H.

N1 - Funding Information: The Gene Targets for IVH Study Group was supported by NIH NS053865. Dr. Zhang was partially supported by NIH R01 DA016750-09. Funding Information: The National Institutes of Health, United States (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR24979 ) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States (Grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, and U10 HD53109 ) provided grant support for the Neonatal Research Networkʼs Genomics Study. In addition, Dr. Murray received assistance for the GENEVA study from the National Human Genome Research Institute, United States ( U01 HG4423 ) and Dr. Aden received support from Swedish Medical Research Council ( 523-2011-3981, 2009-4250, and 523-2009-7054 ), the regional agreement on medical training and clinical research (ALF 20140316) between Stockholm County Council and the Karolinska Institutet, the Marianne and Marcus Wallenberg foundation ( MMW 2011.0085 ), and the Swedish Brain Foundation ( FP2014-0135 ). The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/12

Y1 - 2015/12

N2 - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

AB - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

KW - GWAS

KW - Genes

KW - Intraventricular hemorrhage

KW - Neonate

KW - Preterm

UR - http://www.scopus.com/inward/record.url?scp=84946738462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946738462&partnerID=8YFLogxK

U2 - 10.1053/j.semperi.2015.09.006

DO - 10.1053/j.semperi.2015.09.006

M3 - Review article

C2 - 26516117

AN - SCOPUS:84946738462

VL - 39

SP - 592

EP - 603

JO - Seminars in Perinatology

JF - Seminars in Perinatology

SN - 0146-0005

IS - 8

ER -

Genes and environment in neonatal intraventricular hemorrhage

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