Abstract
Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 592-603 |
| Number of pages | 12 |
| Journal | Seminars in Perinatology |
| Volume | 39 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 2015 |
Keywords
- GWAS
- Genes
- Intraventricular hemorrhage
- Neonate
- Preterm
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
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Genes and environment in neonatal intraventricular hemorrhage. / Ment, Laura R.; Ådén, Ulrika; Bauer, Charles R.; Bada, Henrietta S.; Carlo, Waldemar A.; Kaiser, Jeffrey R.; Lin, Aiping; Cotten, Charles Michael; Murray, Jeffrey; Page, Grier; Hallman, Mikko; Lifton, Richard P.; Zhang, Heping; Bryant, Cindy; Cassady, Christopher; Garcia, Carmen; Johnson, Yvette R.; Karpen, Heidi E.; Munden, Martha M.; Shores, Geneva; Cassese, John; Hensman, Angelita M.; Vieira, Elisa; Vohr, Betty; Wallach, Michael; Cummings, James J.; MacGilvray, Scott S.; Moseley, Sherry; Trapanotto, Vickie; Poindexter, Brenda; Wilson, Leslie Dawn; Wright-Coltart, Shirley; Bartocci, Marco; Printz, Gordana; Hopper, Andrew; Smith, Leon; Wood, Beverly P.; Young, Lionel; Allan, Walter C.; Alfsson, Jessica; Sävman, Karin; Royal, Stuart A.; Young, Daniel W.; Cosby, Shirley; Helms, Crystal; Angtuaco, Teresita; Carol Sikes, N.; Mason, Melanie J.; Whit Hall, R.; Bada, Henrietta; Challa, Harigovinda R.; Grider, Deborah L.; Kriss, Vesna; Whitehead, Vicki; Abdenour, George; Bauer, Charles; Danton, Gary; Montesinos, Daniel; Gaurav, Saigal; Philias, Willy; Teomete, Uygar; Barks, John; Christensen, Mary; Sanchez, Ramon; Sieg, Makayla; Wiggins, Stephanie; Fuller, Janell; Hartenberger, Carol; Montman, Rebecca; Williams, Jessica B.; Williamson, Susan; Bose, Carl; Clark, Cynthia L.; Laughon, Matthew; Abbasi, Soraya; Cook, Noah M.; Mancini, Toni; Chaudhary, Aasma; DeMauro, Christopher; Schmidt, Barbara; Dean, Ellen; Eyal, Fabien; Maertens, Paul; Boulden, Thomas F.; Cohen, Harris L.; Dempsey, Shelia; LeNoue, Pam; Pourcyrous, Massroor; Bird, Karie; Faix, Roger G.; Hedlund, Gary; Moore, Kevin; Osborne, Karen; Weaver-Lewis, Kimberlee; Yoder, Bradley A.; Mayock, Dennis E.; Dighe, Manjiri; Brown, Patricia L.; Michael O'Shea, T.; Peters, Nancy; Inder, Terrie; Lukas, Karen; Mathur, Amit; McKinstry, Robert; Shimony, Joshua; Joshi, Aparna; Ann Nelson, Jay; Shankaran, Seetha; Woldt, Eunice H.; Baker, Kenneth; Bizzarro, Matthew J.; Choi, Murim; Ehrenkranz, Richard; Farhi, Anita; Goodman, T. R.; Katz, Karol; Konstantino, Monica; Liu, Zhifa; Maller-Kesselman, Jill; Nelson-Williams, Carol; Min, Xiaoyi; Walsh, Michele C.; Fanaroff, Avroy A.; Newman, Nancy S.; Siner, Bonnie S.; Schibler, Kurt; Donovan, Edward F.; Narendran, Vivek; Alexander, Barbara; Grisby, Cathy; Hessling, Jody; Mersmann, Marcia Worley; Mincey, Holly L.; Michael Cotten, C.; Goldberg, Ronald N.; Auten, Kathy J.; Stoll, Barbara J.; Hale, Ellen C.; Higgins, Rosemary D.; Wright, Linda L.; Yaffe, Sumner J.; McClure, Elizabeth M.; Archer, Stephanie Wilson; Das, Abhik; McDonald, Scott A.; Poole, W. Kenneth; Hastings, Betty K.; O'Donnell Auman, Jeanette; Zaterka-Baxter, Kristin M.; Van Meurs, Krisa P.; Stevenson, David K.; Ball, M. Bethany; Ambalavanan, Namasivayam; Collins, Monica V.; Cosby, Shirley S.; Finer, Neil N.; Rasmussen, Maynard R.; Kaegi, David; Arnell, Kathy; Demetrio, Clarence; Rich, Wade; Bell, Edward F.; Johnson, Karen J.; Murray, Jeffrey C.; Duara, Shahnaz; Everett-Thomas, Ruth; Korones, Sheldon B.; Hudson, Tina; Sánchez, Pablo J.; Laptook, Abbot R.; Salhab, Walid A.; Madison, Susie; Miller, Nancy A.; Hensley, Gaynelle; Guzman, Alicia; Kennedy, Kathleen A.; Tyson, Jon E.; Akpa, Esther G.; Cluff, Patty A.; Franco, Claudia I.; Lis, Anna E.; McDavid, Georgia E.; Tate, Patti Pierce; Sood, Beena G.; Ganesh Konduri, G.; Bara, Rebecca; Muran, Geraldine; Jobe, Alan H.
In: Seminars in Perinatology, Vol. 39, No. 8, 12.2015, p. 592-603.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Genes and environment in neonatal intraventricular hemorrhage
AU - Ment, Laura R.
AU - Ådén, Ulrika
AU - Bauer, Charles R.
AU - Bada, Henrietta S.
AU - Carlo, Waldemar A.
AU - Kaiser, Jeffrey R.
AU - Lin, Aiping
AU - Cotten, Charles Michael
AU - Murray, Jeffrey
AU - Page, Grier
AU - Hallman, Mikko
AU - Lifton, Richard P.
AU - Zhang, Heping
AU - Bryant, Cindy
AU - Cassady, Christopher
AU - Garcia, Carmen
AU - Johnson, Yvette R.
AU - Karpen, Heidi E.
AU - Munden, Martha M.
AU - Shores, Geneva
AU - Cassese, John
AU - Hensman, Angelita M.
AU - Vieira, Elisa
AU - Vohr, Betty
AU - Wallach, Michael
AU - Cummings, James J.
AU - MacGilvray, Scott S.
AU - Moseley, Sherry
AU - Trapanotto, Vickie
AU - Poindexter, Brenda
AU - Wilson, Leslie Dawn
AU - Wright-Coltart, Shirley
AU - Bartocci, Marco
AU - Printz, Gordana
AU - Hopper, Andrew
AU - Smith, Leon
AU - Wood, Beverly P.
AU - Young, Lionel
AU - Allan, Walter C.
AU - Alfsson, Jessica
AU - Sävman, Karin
AU - Royal, Stuart A.
AU - Young, Daniel W.
AU - Cosby, Shirley
AU - Helms, Crystal
AU - Angtuaco, Teresita
AU - Carol Sikes, N.
AU - Mason, Melanie J.
AU - Whit Hall, R.
AU - Bada, Henrietta
AU - Challa, Harigovinda R.
AU - Grider, Deborah L.
AU - Kriss, Vesna
AU - Whitehead, Vicki
AU - Abdenour, George
AU - Bauer, Charles
AU - Danton, Gary
AU - Montesinos, Daniel
AU - Gaurav, Saigal
AU - Philias, Willy
AU - Teomete, Uygar
AU - Barks, John
AU - Christensen, Mary
AU - Sanchez, Ramon
AU - Sieg, Makayla
AU - Wiggins, Stephanie
AU - Fuller, Janell
AU - Hartenberger, Carol
AU - Montman, Rebecca
AU - Williams, Jessica B.
AU - Williamson, Susan
AU - Bose, Carl
AU - Clark, Cynthia L.
AU - Laughon, Matthew
AU - Abbasi, Soraya
AU - Cook, Noah M.
AU - Mancini, Toni
AU - Chaudhary, Aasma
AU - DeMauro, Christopher
AU - Schmidt, Barbara
AU - Dean, Ellen
AU - Eyal, Fabien
AU - Maertens, Paul
AU - Boulden, Thomas F.
AU - Cohen, Harris L.
AU - Dempsey, Shelia
AU - LeNoue, Pam
AU - Pourcyrous, Massroor
AU - Bird, Karie
AU - Faix, Roger G.
AU - Hedlund, Gary
AU - Moore, Kevin
AU - Osborne, Karen
AU - Weaver-Lewis, Kimberlee
AU - Yoder, Bradley A.
AU - Mayock, Dennis E.
AU - Dighe, Manjiri
AU - Brown, Patricia L.
AU - Michael O'Shea, T.
AU - Peters, Nancy
AU - Inder, Terrie
AU - Lukas, Karen
AU - Mathur, Amit
AU - McKinstry, Robert
AU - Shimony, Joshua
AU - Joshi, Aparna
AU - Ann Nelson, Jay
AU - Shankaran, Seetha
AU - Woldt, Eunice H.
AU - Baker, Kenneth
AU - Bizzarro, Matthew J.
AU - Choi, Murim
AU - Ehrenkranz, Richard
AU - Farhi, Anita
AU - Goodman, T. R.
AU - Katz, Karol
AU - Konstantino, Monica
AU - Liu, Zhifa
AU - Maller-Kesselman, Jill
AU - Nelson-Williams, Carol
AU - Min, Xiaoyi
AU - Walsh, Michele C.
AU - Fanaroff, Avroy A.
AU - Newman, Nancy S.
AU - Siner, Bonnie S.
AU - Schibler, Kurt
AU - Donovan, Edward F.
AU - Narendran, Vivek
AU - Alexander, Barbara
AU - Grisby, Cathy
AU - Hessling, Jody
AU - Mersmann, Marcia Worley
AU - Mincey, Holly L.
AU - Michael Cotten, C.
AU - Goldberg, Ronald N.
AU - Auten, Kathy J.
AU - Stoll, Barbara J.
AU - Hale, Ellen C.
AU - Higgins, Rosemary D.
AU - Wright, Linda L.
AU - Yaffe, Sumner J.
AU - McClure, Elizabeth M.
AU - Archer, Stephanie Wilson
AU - Das, Abhik
AU - McDonald, Scott A.
AU - Poole, W. Kenneth
AU - Hastings, Betty K.
AU - O'Donnell Auman, Jeanette
AU - Zaterka-Baxter, Kristin M.
AU - Van Meurs, Krisa P.
AU - Stevenson, David K.
AU - Ball, M. Bethany
AU - Ambalavanan, Namasivayam
AU - Collins, Monica V.
AU - Cosby, Shirley S.
AU - Finer, Neil N.
AU - Rasmussen, Maynard R.
AU - Kaegi, David
AU - Arnell, Kathy
AU - Demetrio, Clarence
AU - Rich, Wade
AU - Bell, Edward F.
AU - Johnson, Karen J.
AU - Murray, Jeffrey C.
AU - Duara, Shahnaz
AU - Everett-Thomas, Ruth
AU - Korones, Sheldon B.
AU - Hudson, Tina
AU - Sánchez, Pablo J.
AU - Laptook, Abbot R.
AU - Salhab, Walid A.
AU - Madison, Susie
AU - Miller, Nancy A.
AU - Hensley, Gaynelle
AU - Guzman, Alicia
AU - Kennedy, Kathleen A.
AU - Tyson, Jon E.
AU - Akpa, Esther G.
AU - Cluff, Patty A.
AU - Franco, Claudia I.
AU - Lis, Anna E.
AU - McDavid, Georgia E.
AU - Tate, Patti Pierce
AU - Sood, Beena G.
AU - Ganesh Konduri, G.
AU - Bara, Rebecca
AU - Muran, Geraldine
AU - Jobe, Alan H.
N1 - Funding Information: The Gene Targets for IVH Study Group was supported by NIH NS053865. Dr. Zhang was partially supported by NIH R01 DA016750-09. Funding Information: The National Institutes of Health, United States (General Clinical Research Center grants M01 RR30, M01 RR32, M01 RR39, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR24979 ) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States (Grants U01 HD36790, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD21415, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27881, U10 HD27904, U10 HD34216, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40689, and U10 HD53109 ) provided grant support for the Neonatal Research Networkʼs Genomics Study. In addition, Dr. Murray received assistance for the GENEVA study from the National Human Genome Research Institute, United States ( U01 HG4423 ) and Dr. Aden received support from Swedish Medical Research Council ( 523-2011-3981, 2009-4250, and 523-2009-7054 ), the regional agreement on medical training and clinical research (ALF 20140316) between Stockholm County Council and the Karolinska Institutet, the Marianne and Marcus Wallenberg foundation ( MMW 2011.0085 ), and the Swedish Brain Foundation ( FP2014-0135 ). The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study.
PY - 2015/12
Y1 - 2015/12
N2 - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
AB - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
KW - GWAS
KW - Genes
KW - Intraventricular hemorrhage
KW - Neonate
KW - Preterm
UR - http://www.scopus.com/inward/record.url?scp=84946738462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946738462&partnerID=8YFLogxK
U2 - 10.1053/j.semperi.2015.09.006
DO - 10.1053/j.semperi.2015.09.006
M3 - Review article
C2 - 26516117
AN - SCOPUS:84946738462
VL - 39
SP - 592
EP - 603
JO - Seminars in Perinatology
JF - Seminars in Perinatology
SN - 0146-0005
IS - 8
ER -