Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

Bruce Beutler; Kasper Hoebe; Philippe Georgel; Koichi Tabeta; Xin Du

doi:10.1016/j.micinf.2004.08.017

Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

Bruce Beutler, Kasper Hoebe, Philippe Georgel, Koichi Tabeta, Xin Du

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lps^d) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review.

Original language	English (US)
Pages (from-to)	1374-1381
Number of pages	8
Journal	Microbes and Infection
Volume	6
Issue number	15
DOIs	https://doi.org/10.1016/j.micinf.2004.08.017
State	Published - 2004

Keywords

Forward genetics
Innate immunity
Mutagenesis
Mutation
N-ethyl-N-nitrosourea
Toll-like receptors

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2004.08.017

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title = "Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses",

abstract = "The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as {"}Toll-like receptors{"} (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lpsd) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review.",

keywords = "Forward genetics, Innate immunity, Mutagenesis, Mutation, N-ethyl-N-nitrosourea, Toll-like receptors",

author = "Bruce Beutler and Kasper Hoebe and Philippe Georgel and Koichi Tabeta and Xin Du",

note = "Funding Information: This work was supported by funding from National Institutes of Health grants R01GM067759, R01GM60031, U54A154523.",

year = "2004",

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T1 - Genetic analysis of innate immunity

T2 - TIR adapter proteins in innate and adaptive immune responses

AU - Beutler, Bruce

AU - Hoebe, Kasper

AU - Georgel, Philippe

AU - Tabeta, Koichi

AU - Du, Xin

N1 - Funding Information: This work was supported by funding from National Institutes of Health grants R01GM067759, R01GM60031, U54A154523.

PY - 2004

Y1 - 2004

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AB - The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lpsd) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review.

KW - Forward genetics

KW - Innate immunity

KW - Mutagenesis

KW - Mutation

KW - N-ethyl-N-nitrosourea

KW - Toll-like receptors

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Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

Abstract

Keywords

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