Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

Bruce Beutler, Kasper Hoebe, Philippe Georgel, Koichi Tabeta, Xin Du

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lpsd) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review.

Original languageEnglish (US)
Pages (from-to)1374-1381
Number of pages8
JournalMicrobes and Infection
Volume6
Issue number15
DOIs
StatePublished - Jan 1 2004

Keywords

  • Forward genetics
  • Innate immunity
  • Mutagenesis
  • Mutation
  • N-ethyl-N-nitrosourea
  • Toll-like receptors

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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