Genetic analysis of resistance to viral infection

Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean Luc Imler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

As machines that reprogramme eukaryotic cells to suit their own purposes, viruses present a difficult problem for multicellular hosts, and indeed, have become one of the central pre-occupations of the immune system. Unable to permanently outpace individual viruses in an evolutionary footrace, higher eukaryotes have evolved broadly active mechanisms with which to sense viruses and suppress their proliferation. These mechanisms have recently been elucidated by a combination of forward and reverse genetic methods. Some of these mechanisms are clearly ancient, whereas others are relatively new. All are remarkably adept at discriminating self from non-self, and allow the host to cope with what might seem an impossible predicament.

Original languageEnglish (US)
Pages (from-to)753-766
Number of pages14
JournalNature Reviews Immunology
Volume7
Issue number10
DOIs
StatePublished - Oct 2007

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Virus Diseases
Viruses
Reverse Genetics
Eukaryotic Cells
Eukaryota
Immune System

ASJC Scopus subject areas

  • Immunology

Cite this

Beutler, B., Eidenschenk, C., Crozat, K., Imler, J. L., Takeuchi, O., Hoffmann, J. A., & Akira, S. (2007). Genetic analysis of resistance to viral infection. Nature Reviews Immunology, 7(10), 753-766. https://doi.org/10.1038/nri2174

Genetic analysis of resistance to viral infection. / Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean Luc; Takeuchi, Osamu; Hoffmann, Jules A.; Akira, Shizuo.

In: Nature Reviews Immunology, Vol. 7, No. 10, 10.2007, p. 753-766.

Research output: Contribution to journalArticle

Beutler, B, Eidenschenk, C, Crozat, K, Imler, JL, Takeuchi, O, Hoffmann, JA & Akira, S 2007, 'Genetic analysis of resistance to viral infection', Nature Reviews Immunology, vol. 7, no. 10, pp. 753-766. https://doi.org/10.1038/nri2174
Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA et al. Genetic analysis of resistance to viral infection. Nature Reviews Immunology. 2007 Oct;7(10):753-766. https://doi.org/10.1038/nri2174
Beutler, Bruce ; Eidenschenk, Celine ; Crozat, Karine ; Imler, Jean Luc ; Takeuchi, Osamu ; Hoffmann, Jules A. ; Akira, Shizuo. / Genetic analysis of resistance to viral infection. In: Nature Reviews Immunology. 2007 ; Vol. 7, No. 10. pp. 753-766.
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