Genetic and clinical risk prediction model for postoperative atrial fibrillation

Matthew J. Kolek, J. Daniel Muehlschlegel, William S. Bush, Babar Parvez, Katherine T. Murray, C. Michael Stein, M. Benjamin Shoemaker, Marcia A. Blair, Kaylen C. Kor, Dan M. Roden, Brian S. Donahue, Amanda A. Fox, Stanton K. Shernan, Charles D. Collard, Simon C. Body, Dawood Darbar

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background - Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome 4q25 locus are associated with PoAF. Here, we tested the hypothesis that a combined clinical and genetic model incorporating atrial fibrillation risk SNPs would be superior to a clinical-only model. Methods and Results - We developed and externally validated clinical and clinical/genetic risk models for PoAF. The discovery and validation cohorts included 556 and 1164 patients, respectively. Clinical variables previously associated with PoAF and 13 SNPs at loci associated with atrial fibrillation in genome-wide association studies were considered. PoAF occurred in 30% and 29% of patients in the discovery and validation cohorts, respectively. In the discovery cohort, a logistic regression model with clinical factors had good discrimination, with an area under the receiver operator characteristic curve of 0.76. The addition of 10 SNPs to the clinical model did not improve discrimination (area under receiver operator characteristic curve, 0.78; P=0.14 for difference between the 2 models). In the validation cohort, the clinical model had good discrimination (area under the receiver operator characteristic curve, 0.69) and addition of genetic variables resulted in a marginal improvement in discrimination (area under receiver operator characteristic curve, 0.72; P<0.0001). Conclusions - We developed and validated a model for the prediction of PoAF containing common clinical variables. Addition of atrial fibrillation susceptibility SNPs did not improve model performance. Tools to accurately predict PoAF are needed to risk stratify patients undergoing coronary artery bypass grafting and identify candidates for prophylactic therapies.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume8
Issue number1
DOIs
StatePublished - Feb 28 2015

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Atrial Fibrillation
Single Nucleotide Polymorphism
Genetic Models
Coronary Artery Bypass
Logistic Models
Genome-Wide Association Study
Chromosomes

Keywords

  • atrial fibrillation
  • cardiac surgery
  • genetics
  • postoperative complication arrhythmia
  • risk model

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kolek, M. J., Muehlschlegel, J. D., Bush, W. S., Parvez, B., Murray, K. T., Stein, C. M., ... Darbar, D. (2015). Genetic and clinical risk prediction model for postoperative atrial fibrillation. Circulation: Arrhythmia and Electrophysiology, 8(1), 25-31. https://doi.org/10.1161/CIRCEP.114.002300

Genetic and clinical risk prediction model for postoperative atrial fibrillation. / Kolek, Matthew J.; Muehlschlegel, J. Daniel; Bush, William S.; Parvez, Babar; Murray, Katherine T.; Stein, C. Michael; Shoemaker, M. Benjamin; Blair, Marcia A.; Kor, Kaylen C.; Roden, Dan M.; Donahue, Brian S.; Fox, Amanda A.; Shernan, Stanton K.; Collard, Charles D.; Body, Simon C.; Darbar, Dawood.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 8, No. 1, 28.02.2015, p. 25-31.

Research output: Contribution to journalArticle

Kolek, MJ, Muehlschlegel, JD, Bush, WS, Parvez, B, Murray, KT, Stein, CM, Shoemaker, MB, Blair, MA, Kor, KC, Roden, DM, Donahue, BS, Fox, AA, Shernan, SK, Collard, CD, Body, SC & Darbar, D 2015, 'Genetic and clinical risk prediction model for postoperative atrial fibrillation', Circulation: Arrhythmia and Electrophysiology, vol. 8, no. 1, pp. 25-31. https://doi.org/10.1161/CIRCEP.114.002300
Kolek, Matthew J. ; Muehlschlegel, J. Daniel ; Bush, William S. ; Parvez, Babar ; Murray, Katherine T. ; Stein, C. Michael ; Shoemaker, M. Benjamin ; Blair, Marcia A. ; Kor, Kaylen C. ; Roden, Dan M. ; Donahue, Brian S. ; Fox, Amanda A. ; Shernan, Stanton K. ; Collard, Charles D. ; Body, Simon C. ; Darbar, Dawood. / Genetic and clinical risk prediction model for postoperative atrial fibrillation. In: Circulation: Arrhythmia and Electrophysiology. 2015 ; Vol. 8, No. 1. pp. 25-31.
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abstract = "Background - Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome 4q25 locus are associated with PoAF. Here, we tested the hypothesis that a combined clinical and genetic model incorporating atrial fibrillation risk SNPs would be superior to a clinical-only model. Methods and Results - We developed and externally validated clinical and clinical/genetic risk models for PoAF. The discovery and validation cohorts included 556 and 1164 patients, respectively. Clinical variables previously associated with PoAF and 13 SNPs at loci associated with atrial fibrillation in genome-wide association studies were considered. PoAF occurred in 30{\%} and 29{\%} of patients in the discovery and validation cohorts, respectively. In the discovery cohort, a logistic regression model with clinical factors had good discrimination, with an area under the receiver operator characteristic curve of 0.76. The addition of 10 SNPs to the clinical model did not improve discrimination (area under receiver operator characteristic curve, 0.78; P=0.14 for difference between the 2 models). In the validation cohort, the clinical model had good discrimination (area under the receiver operator characteristic curve, 0.69) and addition of genetic variables resulted in a marginal improvement in discrimination (area under receiver operator characteristic curve, 0.72; P<0.0001). Conclusions - We developed and validated a model for the prediction of PoAF containing common clinical variables. Addition of atrial fibrillation susceptibility SNPs did not improve model performance. Tools to accurately predict PoAF are needed to risk stratify patients undergoing coronary artery bypass grafting and identify candidates for prophylactic therapies.",
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T1 - Genetic and clinical risk prediction model for postoperative atrial fibrillation

AU - Kolek, Matthew J.

AU - Muehlschlegel, J. Daniel

AU - Bush, William S.

AU - Parvez, Babar

AU - Murray, Katherine T.

AU - Stein, C. Michael

AU - Shoemaker, M. Benjamin

AU - Blair, Marcia A.

AU - Kor, Kaylen C.

AU - Roden, Dan M.

AU - Donahue, Brian S.

AU - Fox, Amanda A.

AU - Shernan, Stanton K.

AU - Collard, Charles D.

AU - Body, Simon C.

AU - Darbar, Dawood

PY - 2015/2/28

Y1 - 2015/2/28

N2 - Background - Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome 4q25 locus are associated with PoAF. Here, we tested the hypothesis that a combined clinical and genetic model incorporating atrial fibrillation risk SNPs would be superior to a clinical-only model. Methods and Results - We developed and externally validated clinical and clinical/genetic risk models for PoAF. The discovery and validation cohorts included 556 and 1164 patients, respectively. Clinical variables previously associated with PoAF and 13 SNPs at loci associated with atrial fibrillation in genome-wide association studies were considered. PoAF occurred in 30% and 29% of patients in the discovery and validation cohorts, respectively. In the discovery cohort, a logistic regression model with clinical factors had good discrimination, with an area under the receiver operator characteristic curve of 0.76. The addition of 10 SNPs to the clinical model did not improve discrimination (area under receiver operator characteristic curve, 0.78; P=0.14 for difference between the 2 models). In the validation cohort, the clinical model had good discrimination (area under the receiver operator characteristic curve, 0.69) and addition of genetic variables resulted in a marginal improvement in discrimination (area under receiver operator characteristic curve, 0.72; P<0.0001). Conclusions - We developed and validated a model for the prediction of PoAF containing common clinical variables. Addition of atrial fibrillation susceptibility SNPs did not improve model performance. Tools to accurately predict PoAF are needed to risk stratify patients undergoing coronary artery bypass grafting and identify candidates for prophylactic therapies.

AB - Background - Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome 4q25 locus are associated with PoAF. Here, we tested the hypothesis that a combined clinical and genetic model incorporating atrial fibrillation risk SNPs would be superior to a clinical-only model. Methods and Results - We developed and externally validated clinical and clinical/genetic risk models for PoAF. The discovery and validation cohorts included 556 and 1164 patients, respectively. Clinical variables previously associated with PoAF and 13 SNPs at loci associated with atrial fibrillation in genome-wide association studies were considered. PoAF occurred in 30% and 29% of patients in the discovery and validation cohorts, respectively. In the discovery cohort, a logistic regression model with clinical factors had good discrimination, with an area under the receiver operator characteristic curve of 0.76. The addition of 10 SNPs to the clinical model did not improve discrimination (area under receiver operator characteristic curve, 0.78; P=0.14 for difference between the 2 models). In the validation cohort, the clinical model had good discrimination (area under the receiver operator characteristic curve, 0.69) and addition of genetic variables resulted in a marginal improvement in discrimination (area under receiver operator characteristic curve, 0.72; P<0.0001). Conclusions - We developed and validated a model for the prediction of PoAF containing common clinical variables. Addition of atrial fibrillation susceptibility SNPs did not improve model performance. Tools to accurately predict PoAF are needed to risk stratify patients undergoing coronary artery bypass grafting and identify candidates for prophylactic therapies.

KW - atrial fibrillation

KW - cardiac surgery

KW - genetics

KW - postoperative complication arrhythmia

KW - risk model

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