Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease

Miao Cui, Zhaoning Wang, Rhonda S Bassel-Duby, Eric N Olson

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells. These cells, termed cardiomyocytes, display many fascinating behaviors, including complex morphogenic movements, interactions with other cell types of the heart, persistent contractility and quiescence after birth. Each of these behaviors depends on complex interactions between both cardiac-restricted and widely expressed transcription factors, as well as on epigenetic modifications. Here, we review recent advances in our understanding of the genetic and epigenetic control of cardiomyocyte differentiation and proliferation during heart development, regeneration and disease. We focus on those regulators that are required for both heart development and disease, and highlight the regenerative principles that might be manipulated to restore function to the injured adult heart.

Original languageEnglish (US)
Article numberdev171983
JournalDevelopment (Cambridge)
Volume145
Issue number24
DOIs
StatePublished - Dec 15 2018

Keywords

  • Cardiac disease remodeling
  • Cardiac transcription factors
  • Cardiogenesis
  • Epigenetic regulator
  • Heart regeneration

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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