Genetic and molecular mapping of the Hmt region of mouse

S. Richards, M. Bucan, K. Brorson, M. C. Kiefer, S. W. Hunt, H. Lehrach, K. Fischer Lindahl

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

Original languageEnglish (US)
Pages (from-to)3749-3757
Number of pages9
JournalEMBO Journal
Volume8
Issue number12
StatePublished - 1989

Fingerprint

MHC Class I Genes
Major Histocompatibility Complex
Molecular Biology
Genes
Chromosomes, Human, Pair 17
Haplotypes
Chromosomes
Antigens

Keywords

  • genome organization
  • maternally transmitted antigen (Mta)
  • MHC class I genes
  • mouse chromosome 17
  • t-complex

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Richards, S., Bucan, M., Brorson, K., Kiefer, M. C., Hunt, S. W., Lehrach, H., & Fischer Lindahl, K. (1989). Genetic and molecular mapping of the Hmt region of mouse. EMBO Journal, 8(12), 3749-3757.

Genetic and molecular mapping of the Hmt region of mouse. / Richards, S.; Bucan, M.; Brorson, K.; Kiefer, M. C.; Hunt, S. W.; Lehrach, H.; Fischer Lindahl, K.

In: EMBO Journal, Vol. 8, No. 12, 1989, p. 3749-3757.

Research output: Contribution to journalArticle

Richards, S, Bucan, M, Brorson, K, Kiefer, MC, Hunt, SW, Lehrach, H & Fischer Lindahl, K 1989, 'Genetic and molecular mapping of the Hmt region of mouse', EMBO Journal, vol. 8, no. 12, pp. 3749-3757.
Richards S, Bucan M, Brorson K, Kiefer MC, Hunt SW, Lehrach H et al. Genetic and molecular mapping of the Hmt region of mouse. EMBO Journal. 1989;8(12):3749-3757.
Richards, S. ; Bucan, M. ; Brorson, K. ; Kiefer, M. C. ; Hunt, S. W. ; Lehrach, H. ; Fischer Lindahl, K. / Genetic and molecular mapping of the Hmt region of mouse. In: EMBO Journal. 1989 ; Vol. 8, No. 12. pp. 3749-3757.
@article{403b02387fec4b018a32a1ad9511fa07,
title = "Genetic and molecular mapping of the Hmt region of mouse",
abstract = "We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.",
keywords = "genome organization, maternally transmitted antigen (Mta), MHC class I genes, mouse chromosome 17, t-complex",
author = "S. Richards and M. Bucan and K. Brorson and Kiefer, {M. C.} and Hunt, {S. W.} and H. Lehrach and {Fischer Lindahl}, K.",
year = "1989",
language = "English (US)",
volume = "8",
pages = "3749--3757",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Genetic and molecular mapping of the Hmt region of mouse

AU - Richards, S.

AU - Bucan, M.

AU - Brorson, K.

AU - Kiefer, M. C.

AU - Hunt, S. W.

AU - Lehrach, H.

AU - Fischer Lindahl, K.

PY - 1989

Y1 - 1989

N2 - We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

AB - We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

KW - genome organization

KW - maternally transmitted antigen (Mta)

KW - MHC class I genes

KW - mouse chromosome 17

KW - t-complex

UR - http://www.scopus.com/inward/record.url?scp=0024819745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024819745&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 3749

EP - 3757

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 12

ER -