Genetic Approaches to Coronary Heart Disease

Jonathan C. Cohen

doi:10.1016/j.jacc.2006.06.046

Genetic Approaches to Coronary Heart Disease

Jonathan C. Cohen

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Developments in high-throughput genotyping have progressed to the point where genome-wide association studies are becoming practical. Multistage designs involving large numbers of sequence variants (∼300,000) and relatively large samples sizes (several hundred cases and control subjects) will be essential to reliably detect alleles with appreciable effect sizes (2-fold increase in relative risk). Direct sequencing of candidate genes in cases and control subjects provides an alternative approach that can reveal low-frequency alleles that influence disease susceptibility. Ultimately, the outcome of both approaches will depend on the genetic architecture of coronary heart disease.

Original language	English (US)
Pages (from-to)	A10-A14
Journal	Journal of the American College of Cardiology
Volume	48
Issue number	9 SUPPL.
DOIs	https://doi.org/10.1016/j.jacc.2006.06.046
State	Published - Nov 7 2006

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacc.2006.06.046

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AB - Developments in high-throughput genotyping have progressed to the point where genome-wide association studies are becoming practical. Multistage designs involving large numbers of sequence variants (∼300,000) and relatively large samples sizes (several hundred cases and control subjects) will be essential to reliably detect alleles with appreciable effect sizes (2-fold increase in relative risk). Direct sequencing of candidate genes in cases and control subjects provides an alternative approach that can reveal low-frequency alleles that influence disease susceptibility. Ultimately, the outcome of both approaches will depend on the genetic architecture of coronary heart disease.

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Genetic Approaches to Coronary Heart Disease

Abstract

ASJC Scopus subject areas

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