Genetic Basis of Murine Lupus Nephritis

Li Li, Chandra Mohan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Systemic lupus erythematosus is a generalized autoimmune disease affecting multiple end-organs including the kidneys. Glomerulonephritis is a leading cause of death in lupus, both in patients and murine models that develop disease spontaneously. Genetic mapping studies have uncovered several genetic intervals that confer susceptibility to nephritis both in human beings and in mice. This review surveys the genomic positions of these nephritis susceptibility loci in murine lupus. Currently we know very little about the molecular identities of the culprit genes within these mapped loci and whether these genetic elements contribute to nephritis directly in a renal-intrinsic fashion or indirectly by augmenting the formation of pathogenic autoantibodies. The next decade is likely to witness a significant broadening of our understanding of how different genes and molecules might facilitate end-organ damage in lupus.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalSeminars in Nephrology
Volume27
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Lupus Nephritis
Nephritis
Kidney
Genetic Loci
Glomerulonephritis
Systemic Lupus Erythematosus
Autoantibodies
Genes
Autoimmune Diseases
Cause of Death

Keywords

  • anti-DNA
  • genetics
  • linkage
  • lupus
  • Nephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

Genetic Basis of Murine Lupus Nephritis. / Li, Li; Mohan, Chandra.

In: Seminars in Nephrology, Vol. 27, No. 1, 01.2007, p. 12-21.

Research output: Contribution to journalArticle

Li, Li ; Mohan, Chandra. / Genetic Basis of Murine Lupus Nephritis. In: Seminars in Nephrology. 2007 ; Vol. 27, No. 1. pp. 12-21.
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