Genetic Characteristics and Cirrhosis: A Controlled Study of 200 Patients

N. C. Reid; P. W. Brunt; W. B. Bias; W. C. Maddrey; B. A. Alonso; F. L. Iber

doi:10.1136/bmj.2.5603.463

Genetic Characteristics and Cirrhosis: A Controlled Study of 200 Patients

N. C. Reid, P. W. Brunt, W. B. Bias, W. C. Maddrey, B. A. Alonso, F. L. Iber

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Abstract

One hundred patients with cirrhosis were compared with control subjects in inherited physical characteristics, colour-blindness, and blood group substances. There was a significant increase among Caucasian cirrhotic subjects with brown hair and very light skin colour compared with controls. Among Negroes an increase in the Duffy blood group was observed in the cirrhotics compared with controls. No increase in colour-blindness was observed in cirrhotic subjects. These studies suggest a broad multifactorial base for susceptibility to cirrhosis and an increased frequency of these factors in Whites compared with non-Whites.

Original language	English (US)
Pages (from-to)	463-465
Number of pages	3
Journal	British Medical Journal
Volume	2
Issue number	5603
DOIs	https://doi.org/10.1136/bmj.2.5603.463
State	Published - May 25 1968

ASJC Scopus subject areas

General Medicine

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title = "Genetic Characteristics and Cirrhosis: A Controlled Study of 200 Patients",

abstract = "One hundred patients with cirrhosis were compared with control subjects in inherited physical characteristics, colour-blindness, and blood group substances. There was a significant increase among Caucasian cirrhotic subjects with brown hair and very light skin colour compared with controls. Among Negroes an increase in the Duffy blood group was observed in the cirrhotics compared with controls. No increase in colour-blindness was observed in cirrhotic subjects. These studies suggest a broad multifactorial base for susceptibility to cirrhosis and an increased frequency of these factors in Whites compared with non-Whites.",

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AU - Reid, N. C.

AU - Brunt, P. W.

AU - Bias, W. B.

AU - Maddrey, W. C.

AU - Alonso, B. A.

AU - Iber, F. L.

PY - 1968/5/25

Y1 - 1968/5/25

N2 - One hundred patients with cirrhosis were compared with control subjects in inherited physical characteristics, colour-blindness, and blood group substances. There was a significant increase among Caucasian cirrhotic subjects with brown hair and very light skin colour compared with controls. Among Negroes an increase in the Duffy blood group was observed in the cirrhotics compared with controls. No increase in colour-blindness was observed in cirrhotic subjects. These studies suggest a broad multifactorial base for susceptibility to cirrhosis and an increased frequency of these factors in Whites compared with non-Whites.

AB - One hundred patients with cirrhosis were compared with control subjects in inherited physical characteristics, colour-blindness, and blood group substances. There was a significant increase among Caucasian cirrhotic subjects with brown hair and very light skin colour compared with controls. Among Negroes an increase in the Duffy blood group was observed in the cirrhotics compared with controls. No increase in colour-blindness was observed in cirrhotic subjects. These studies suggest a broad multifactorial base for susceptibility to cirrhosis and an increased frequency of these factors in Whites compared with non-Whites.

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Genetic Characteristics and Cirrhosis: A Controlled Study of 200 Patients

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