Genetic control of extraglandular aromatase activity in the chicken

Jean D. Wilson, Fredrick W. George, Mark Leshin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Feminization of feathers in the Sebright cock is the result of increase in the activity of skin aromatase. This increased estrogen synthesis is the consequence of an autosomal dominant mutation that causes an increase in the specific androgen-binding cytochrome P450 oxidase involved in the reaction. Since this oxidase appears to be kinetically indistinguishable from the activity in control ovary we believe that the mutation causes an increased steady-state level of normal enzyme. The mechanism by which the mutation acts is unknown, but its presence implies that in normal birds an allele of the mutation limits the activity of the enzyme in all tissues other than ovary.

Original languageEnglish (US)
Pages (from-to)235-244
Number of pages10
JournalSteroids
Volume50
Issue number1-3
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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