Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis

D. J. Wolgemuth, K. Rhee, S. Wu, S. E. Ravnik

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (Hi) strategies that can be used to identify additional cell cycle regulating genes are outlined.

Original languageEnglish (US)
Pages (from-to)669-684
Number of pages16
JournalReproduction, Fertility and Development
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1995

Keywords

  • Cyclin-dependent kinases
  • Cyclins
  • Phosphatases

ASJC Scopus subject areas

  • Biotechnology
  • Reproductive Medicine
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Developmental Biology

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