Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis.

D. J. Wolgemuth, K. Rhee, S. Wu, S. E. Ravnik

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (iii) strategies that can be used to identify additional cell cycle regulating genes are outlined.

Original languageEnglish (US)
Pages (from-to)669-683
Number of pages15
JournalReproduction, fertility, and development
Volume7
Issue number4
StatePublished - 1995

Fingerprint

Meiosis
Spermatogenesis
spermatogenesis
Mitosis
meiosis
mitosis
Gametogenesis
cell cycle
Cell Cycle
Cell Cycle Checkpoints
Mammals
Yeasts
cdc Genes
gametogenesis
Eukaryotic Cells
Germ Cells
mammals
yeasts
Cell Line
eukaryotic cells

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Reproductive Medicine
  • Developmental Biology
  • Endocrinology

Cite this

Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis. / Wolgemuth, D. J.; Rhee, K.; Wu, S.; Ravnik, S. E.

In: Reproduction, fertility, and development, Vol. 7, No. 4, 1995, p. 669-683.

Research output: Contribution to journalArticle

@article{6c67af3da73d4df8b171caa6b5eaf0d9,
title = "Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis.",
abstract = "Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (iii) strategies that can be used to identify additional cell cycle regulating genes are outlined.",
author = "Wolgemuth, {D. J.} and K. Rhee and S. Wu and Ravnik, {S. E.}",
year = "1995",
language = "English (US)",
volume = "7",
pages = "669--683",
journal = "Reproduction, Fertility and Development",
issn = "1031-3613",
publisher = "CSIRO",
number = "4",

}

TY - JOUR

T1 - Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis.

AU - Wolgemuth, D. J.

AU - Rhee, K.

AU - Wu, S.

AU - Ravnik, S. E.

PY - 1995

Y1 - 1995

N2 - Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (iii) strategies that can be used to identify additional cell cycle regulating genes are outlined.

AB - Gametogenesis in both the male and female mammal represents a specialized and highly regulated series of cell cycle events, involving both mitosis and meiosis as well as subsequent differentiation. Recent advances in our understanding of the genetic control of the eukaryotic cell cycle have underscored the evolutionarily-conserved nature of these regulatory processes. However, most of the data have been obtained from yeast model systems and mammalian cell lines. Furthermore, most of the observations focus on regulation of mitotic cell cycles. In the present paper: (i) aspects of gametogenesis in mammals that represent unique cell-cycle control points are highlighted; (ii) current knowledge on the regulation of the germ cell cycle, in the context of what is known in yeast and other model eukaryotic systems, is summarized; and (iii) strategies that can be used to identify additional cell cycle regulating genes are outlined.

UR - http://www.scopus.com/inward/record.url?scp=0029451709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029451709&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 669

EP - 683

JO - Reproduction, Fertility and Development

JF - Reproduction, Fertility and Development

SN - 1031-3613

IS - 4

ER -