Genetic dissection of systemic lupus erythematosus

Edward K. Wakeland, Amy E. Wandstrat, Kui Liu, Laurence Morel

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalCurrent Opinion in Immunology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 1999

Fingerprint

Systemic Lupus Erythematosus
Dissection
Autoimmunity
Genes
Genetic Predisposition to Disease
Animal Models

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic dissection of systemic lupus erythematosus. / Wakeland, Edward K.; Wandstrat, Amy E.; Liu, Kui; Morel, Laurence.

In: Current Opinion in Immunology, Vol. 11, No. 6, 01.12.1999, p. 701-707.

Research output: Contribution to journalArticle

Wakeland, Edward K. ; Wandstrat, Amy E. ; Liu, Kui ; Morel, Laurence. / Genetic dissection of systemic lupus erythematosus. In: Current Opinion in Immunology. 1999 ; Vol. 11, No. 6. pp. 701-707.
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