Genetic dissection of systemic lupus erythematosus

Edward K. Wakeland, Amy E. Wandstrat, Kui Liu, Laurence Morel

Research output: Contribution to journalReview article

132 Scopus citations


Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1 1999


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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