Genetic factors for the development of Alzheimer disease in the Cherokee Indian

Roger N. Rosenberg, Ralph W. Richter, Richard C. Risser, Kevin Taubman, Ivette Prado-Farmer, Eleanor Ebalo, JoAnne Posey, David Kingfisher, David Dean, Myron F. Weiner, Doris Svetlik, Perrie Adams, Lawrence S. Honig, C. Munro Cullum, Frederick V. Schaefer, Gerard D. Schellenberg

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: To study the relationship between the genetic degree of Cherokee ancestry, the apolipoprotein E *E4 (APOE*E4) allele type, and the development of Alzheimer disease (AD) in individuals from the Cherokee Nation who reside in northeastern Oklahoma. Setting: Alzheimer disease center satellite clinic and university departments of neurology, psychiatry, and academic computing. Design: Standardized dementia evaluations based on criteria from the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association were performed on 26 patients aged 65 years or older to establish a diagnosis of AD. Twenty-six control subjects were recruited and similarly assessed. The APOE allele type determinations were obtained on all patients and control subjects. Appropriate statistical analyses were used to compare the genetic degree of Cherokee ancestry, the APOE allele type, and the development of AD. Results: The data indicated that as the genetic degree of Cherokee Indian ancestry increased, the representation of AD decreased. The 9 patients with AD with a greater than 50% genetic degree of Cherokee ancestry constituted 35% of the group with AD. The 17 remaining patients with AD who were less than 50% Cherokee constituted 65% of the group with AD. In contrast, 17 (65%) of the control subjects were more than 50% Cherokee; only 9 (35%) were less than 50% Cherokee. These percentages of AD were not changed by the *E4 allele. This inverse relationship between the genetic degree of Cherokee ancestry and AD, independent of the APOE*E4 allele status, diminished with increasing age, suggesting an age-related protective effect of being Cherokee. For a decrease of 10% in Cherokee ancestry, the odds of developing AD are estimated to be 9.00 times greater at age 65 years but only 1.34 times greater at age 80 years. Conclusions: A greater genetic degree of Cherokee ancestry reduces the risk of developing AD and, thus, seems protective. This protective genetic factor is independent of APOE allele type and diminishes with age.

Original languageEnglish (US)
Pages (from-to)997-1000
Number of pages4
JournalArchives of Neurology
Volume53
Issue number10
StatePublished - Oct 1996

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Alzheimer Disease
Alleles
Apolipoproteins E
Alzheimer's Disease
Cherokee
National Institute of Neurological Disorders and Stroke
Communication Disorders
Apolipoprotein E4
Community Health Centers
Neurology
Ancestry
Psychiatry
Dementia
Allele

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rosenberg, R. N., Richter, R. W., Risser, R. C., Taubman, K., Prado-Farmer, I., Ebalo, E., ... Schellenberg, G. D. (1996). Genetic factors for the development of Alzheimer disease in the Cherokee Indian. Archives of Neurology, 53(10), 997-1000.

Genetic factors for the development of Alzheimer disease in the Cherokee Indian. / Rosenberg, Roger N.; Richter, Ralph W.; Risser, Richard C.; Taubman, Kevin; Prado-Farmer, Ivette; Ebalo, Eleanor; Posey, JoAnne; Kingfisher, David; Dean, David; Weiner, Myron F.; Svetlik, Doris; Adams, Perrie; Honig, Lawrence S.; Cullum, C. Munro; Schaefer, Frederick V.; Schellenberg, Gerard D.

In: Archives of Neurology, Vol. 53, No. 10, 10.1996, p. 997-1000.

Research output: Contribution to journalArticle

Rosenberg, RN, Richter, RW, Risser, RC, Taubman, K, Prado-Farmer, I, Ebalo, E, Posey, J, Kingfisher, D, Dean, D, Weiner, MF, Svetlik, D, Adams, P, Honig, LS, Cullum, CM, Schaefer, FV & Schellenberg, GD 1996, 'Genetic factors for the development of Alzheimer disease in the Cherokee Indian', Archives of Neurology, vol. 53, no. 10, pp. 997-1000.
Rosenberg RN, Richter RW, Risser RC, Taubman K, Prado-Farmer I, Ebalo E et al. Genetic factors for the development of Alzheimer disease in the Cherokee Indian. Archives of Neurology. 1996 Oct;53(10):997-1000.
Rosenberg, Roger N. ; Richter, Ralph W. ; Risser, Richard C. ; Taubman, Kevin ; Prado-Farmer, Ivette ; Ebalo, Eleanor ; Posey, JoAnne ; Kingfisher, David ; Dean, David ; Weiner, Myron F. ; Svetlik, Doris ; Adams, Perrie ; Honig, Lawrence S. ; Cullum, C. Munro ; Schaefer, Frederick V. ; Schellenberg, Gerard D. / Genetic factors for the development of Alzheimer disease in the Cherokee Indian. In: Archives of Neurology. 1996 ; Vol. 53, No. 10. pp. 997-1000.
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abstract = "Objective: To study the relationship between the genetic degree of Cherokee ancestry, the apolipoprotein E *E4 (APOE*E4) allele type, and the development of Alzheimer disease (AD) in individuals from the Cherokee Nation who reside in northeastern Oklahoma. Setting: Alzheimer disease center satellite clinic and university departments of neurology, psychiatry, and academic computing. Design: Standardized dementia evaluations based on criteria from the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association were performed on 26 patients aged 65 years or older to establish a diagnosis of AD. Twenty-six control subjects were recruited and similarly assessed. The APOE allele type determinations were obtained on all patients and control subjects. Appropriate statistical analyses were used to compare the genetic degree of Cherokee ancestry, the APOE allele type, and the development of AD. Results: The data indicated that as the genetic degree of Cherokee Indian ancestry increased, the representation of AD decreased. The 9 patients with AD with a greater than 50{\%} genetic degree of Cherokee ancestry constituted 35{\%} of the group with AD. The 17 remaining patients with AD who were less than 50{\%} Cherokee constituted 65{\%} of the group with AD. In contrast, 17 (65{\%}) of the control subjects were more than 50{\%} Cherokee; only 9 (35{\%}) were less than 50{\%} Cherokee. These percentages of AD were not changed by the *E4 allele. This inverse relationship between the genetic degree of Cherokee ancestry and AD, independent of the APOE*E4 allele status, diminished with increasing age, suggesting an age-related protective effect of being Cherokee. For a decrease of 10{\%} in Cherokee ancestry, the odds of developing AD are estimated to be 9.00 times greater at age 65 years but only 1.34 times greater at age 80 years. Conclusions: A greater genetic degree of Cherokee ancestry reduces the risk of developing AD and, thus, seems protective. This protective genetic factor is independent of APOE allele type and diminishes with age.",
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AU - Richter, Ralph W.

AU - Risser, Richard C.

AU - Taubman, Kevin

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AU - Ebalo, Eleanor

AU - Posey, JoAnne

AU - Kingfisher, David

AU - Dean, David

AU - Weiner, Myron F.

AU - Svetlik, Doris

AU - Adams, Perrie

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AU - Cullum, C. Munro

AU - Schaefer, Frederick V.

AU - Schellenberg, Gerard D.

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