Genetic hypercalciuria

Orson W. Moe, Olivier Bonny

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon.

Original languageEnglish (US)
Pages (from-to)729-745
Number of pages17
JournalJournal of the American Society of Nephrology
Volume16
Issue number3
DOIs
StatePublished - 2005

Fingerprint

Hypercalciuria
Databases

ASJC Scopus subject areas

  • Nephrology

Cite this

Genetic hypercalciuria. / Moe, Orson W.; Bonny, Olivier.

In: Journal of the American Society of Nephrology, Vol. 16, No. 3, 2005, p. 729-745.

Research output: Contribution to journalArticle

Moe, Orson W. ; Bonny, Olivier. / Genetic hypercalciuria. In: Journal of the American Society of Nephrology. 2005 ; Vol. 16, No. 3. pp. 729-745.
@article{1a788612a96a4d31a2effdf2c608b826,
title = "Genetic hypercalciuria",
abstract = "Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon.",
author = "Moe, {Orson W.} and Olivier Bonny",
year = "2005",
doi = "10.1681/ASN.2004100888",
language = "English (US)",
volume = "16",
pages = "729--745",
journal = "Journal of the American Society of Nephrology",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "3",

}

TY - JOUR

T1 - Genetic hypercalciuria

AU - Moe, Orson W.

AU - Bonny, Olivier

PY - 2005

Y1 - 2005

N2 - Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon.

AB - Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon.

UR - http://www.scopus.com/inward/record.url?scp=20544455158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20544455158&partnerID=8YFLogxK

U2 - 10.1681/ASN.2004100888

DO - 10.1681/ASN.2004100888

M3 - Article

C2 - 15689405

AN - SCOPUS:20544455158

VL - 16

SP - 729

EP - 745

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

SN - 1046-6673

IS - 3

ER -