Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1

J. M. Vance, M. A. Pericak-Vance, L. H. Yamaoka, M. C. Speer, G. O D Rosenwasser, K. Small, P. C. Gaskell, W. Y. Hung, M. J. Alberts, C. S. Haynes, J. R. Gilbert, A. S. Aylsworth, A. D. Roses

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Abstract

The von Recklinghausen neurofibromatosis (NF1) gene has been localized to the pericentromeric region of chromosome 17. We have screened six multigenerational families with multiple, tightly linked markers to aid in mapping this region of the chromosome. More than 150 members in six families were typed with probes including HHH202, D17Z1, EW203, EW206, EW207, EW301, pA10-41, D17S37, and D17S36. Two-point lod scores for NF1 versus all markers were calculated. HHH202 demonstrated the tightest linkage to NF1 were θ = .0, z = 3.86 (95% confidence limits [CL] of θ = .0-.13), suggesting that HHH202 be considered as a potential candidate marker for use in carrier detection and prenatal diagnosis. Pairwise marker-to-marker lod scores were used in examining the most likely order of subsets of the markers. Of those tested, the most likely order was (pter)-pA10-41-EW301-D17Z1-HHH202-NF1-EW206-EW207-EW203-(qter). In addition, we have ascertained an NF1 x NF1 half-cousin mating in which there are four affected family members who are potentially homozygous for the disease gene. Two of these four individuals have been sampled and typed for marker loci. When their D17Z1 genotypes are considered, the probability that both these individuals are heterozygous is 85%.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalAmerican Journal of Human Genetics
Volume44
Issue number1
StatePublished - 1989

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Chromosomes, Human, Pair 17
Neurofibromatosis 1
Genetic Linkage
Chromosome Mapping
Genetic Markers
Lod Score
Neurofibromatoses
Prenatal Diagnosis
Genes
Genotype

ASJC Scopus subject areas

  • Genetics

Cite this

Vance, J. M., Pericak-Vance, M. A., Yamaoka, L. H., Speer, M. C., Rosenwasser, G. O. D., Small, K., ... Roses, A. D. (1989). Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1. American Journal of Human Genetics, 44(1), 25-29.

Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1. / Vance, J. M.; Pericak-Vance, M. A.; Yamaoka, L. H.; Speer, M. C.; Rosenwasser, G. O D; Small, K.; Gaskell, P. C.; Hung, W. Y.; Alberts, M. J.; Haynes, C. S.; Gilbert, J. R.; Aylsworth, A. S.; Roses, A. D.

In: American Journal of Human Genetics, Vol. 44, No. 1, 1989, p. 25-29.

Research output: Contribution to journalArticle

Vance, JM, Pericak-Vance, MA, Yamaoka, LH, Speer, MC, Rosenwasser, GOD, Small, K, Gaskell, PC, Hung, WY, Alberts, MJ, Haynes, CS, Gilbert, JR, Aylsworth, AS & Roses, AD 1989, 'Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1', American Journal of Human Genetics, vol. 44, no. 1, pp. 25-29.
Vance JM, Pericak-Vance MA, Yamaoka LH, Speer MC, Rosenwasser GOD, Small K et al. Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1. American Journal of Human Genetics. 1989;44(1):25-29.
Vance, J. M. ; Pericak-Vance, M. A. ; Yamaoka, L. H. ; Speer, M. C. ; Rosenwasser, G. O D ; Small, K. ; Gaskell, P. C. ; Hung, W. Y. ; Alberts, M. J. ; Haynes, C. S. ; Gilbert, J. R. ; Aylsworth, A. S. ; Roses, A. D. / Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type 1. In: American Journal of Human Genetics. 1989 ; Vol. 44, No. 1. pp. 25-29.
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