Genetic modeling of gliomas in mice: New tools to tackle old problems

Dolores Hambardzumyan, Luis F. Parada, Eric C. Holland, Al Charest

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The recently published comprehensive profiles of genomic alterations in glioma have led to a refinement in our understanding of the molecular events that underlie this cancer. Using state-of-the-art genomic tools, several laboratories have created and characterized accurate genetically engineered mouse models of glioma based on specific genetic alterations observed in human tumors. These in vivo brain tumor models faithfully recapitulate the histopathology, etiology, and biology of gliomas and provide an exceptional experimental system to discover novel therapeutic targets and test therapeutic agents. This review focuses on mouse models of glioma with a special emphasis on genetically engineered models developed around key genetic glioma signature mutations in the PDGFR, EGFR, and NF1 genes and pathways. The resulting animal models have provided insight into many fundamental and mechanistic facets of tumor initiation, maintenance and resistance to therapeutic intervention and will continue to do so in the future.

Original languageEnglish (US)
Pages (from-to)1155-1168
Number of pages14
JournalGLIA
Volume59
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Glioma
erbB-1 Genes
Neoplasms
Brain Neoplasms
Therapeutics
Animal Models
Maintenance
Mutation

Keywords

  • EGFR
  • Glioma
  • Mouse models
  • NF1
  • PDGF

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Hambardzumyan, D., Parada, L. F., Holland, E. C., & Charest, A. (2011). Genetic modeling of gliomas in mice: New tools to tackle old problems. GLIA, 59(8), 1155-1168. https://doi.org/10.1002/glia.21142

Genetic modeling of gliomas in mice : New tools to tackle old problems. / Hambardzumyan, Dolores; Parada, Luis F.; Holland, Eric C.; Charest, Al.

In: GLIA, Vol. 59, No. 8, 08.2011, p. 1155-1168.

Research output: Contribution to journalArticle

Hambardzumyan, D, Parada, LF, Holland, EC & Charest, A 2011, 'Genetic modeling of gliomas in mice: New tools to tackle old problems', GLIA, vol. 59, no. 8, pp. 1155-1168. https://doi.org/10.1002/glia.21142
Hambardzumyan D, Parada LF, Holland EC, Charest A. Genetic modeling of gliomas in mice: New tools to tackle old problems. GLIA. 2011 Aug;59(8):1155-1168. https://doi.org/10.1002/glia.21142
Hambardzumyan, Dolores ; Parada, Luis F. ; Holland, Eric C. ; Charest, Al. / Genetic modeling of gliomas in mice : New tools to tackle old problems. In: GLIA. 2011 ; Vol. 59, No. 8. pp. 1155-1168.
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