Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera

James M. Foppoli, Lean Kuan Ch'ng, Albert A. Benedict, Juraj Ivanyi, Josef Derka, Edward K. Wakeland

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by the M-1 locus were less polymorphic. Nine G-1 and four M-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations of G-1 or M-1 specificities. Five additional G-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of the G-1:M-1 haplotypes theoretically expected, were detected in inbred lines.

Original languageEnglish (US)
Pages (from-to)385-404
Number of pages20
JournalImmunogenetics
Volume8
Issue number1
DOIs
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Immunology
  • Genetics

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