Genetic polymorphisms of debrisoquine and S-mephenytoin oxidation metabolism in Chinese populations

A meta-analysis

Hong Guang Xie, Zhen Hua Xu, Xiang Luo, Song Lin Huang, Fan Dian Zeng, Hong Hao Zhou

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Chinese data on the polymorphic metabolism of debrisoquine metoprolol, codeine and mephenytoin were collected and reanalysed using a meta-analysis method. There were no significant differences in the incidences of poor metabolizer (PM) between the separate series of debrisoquine, metoprolol and codeine, which are the three probe drugs reflecting the same enzyme polymorphism. PMs were detected at low frequencies for debrisoquine (1.20%; 95% confidence interval, CI: 0.67-1.98%), metoprolol (0.72%; CI: 0.29-1.49%) and codeine (0.48%, CI: 0.01-2.68%). The overall estimate of PM was 0.95% (CI: 0.60-1.42%) based on the 2427 determinations of all three probe drugs. The overall mean of PM of mephenytoin was 14.32% (12.26-16.38%) in the 1117 subjects. In summary, the present meta-analysis determined the accurate incidences of the genetic deficiency of S-mephenytoin 4'-hydroxylase (cytochrome P450 2C19) and debrisoquine hydroxylase (cytochrome P450 2D6) in Chinese populations.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalPharmacogenetics
Volume6
Issue number3
DOIs
StatePublished - 1996

Fingerprint

Mephenytoin
Debrisoquin
Codeine
Metoprolol
Genetic Polymorphisms
Meta-Analysis
Cytochrome P-450 CYP2D6
Population
Incidence
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Confidence Intervals
Enzymes

Keywords

  • Chinese meta-analysis
  • Codeine
  • CYP2C19
  • CYP2D6
  • Debrisoquine
  • Mephenytoin
  • Metoprolol
  • Phenotyping

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Genetic polymorphisms of debrisoquine and S-mephenytoin oxidation metabolism in Chinese populations : A meta-analysis. / Xie, Hong Guang; Xu, Zhen Hua; Luo, Xiang; Huang, Song Lin; Zeng, Fan Dian; Zhou, Hong Hao.

In: Pharmacogenetics, Vol. 6, No. 3, 1996, p. 235-238.

Research output: Contribution to journalArticle

Xie, Hong Guang ; Xu, Zhen Hua ; Luo, Xiang ; Huang, Song Lin ; Zeng, Fan Dian ; Zhou, Hong Hao. / Genetic polymorphisms of debrisoquine and S-mephenytoin oxidation metabolism in Chinese populations : A meta-analysis. In: Pharmacogenetics. 1996 ; Vol. 6, No. 3. pp. 235-238.
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abstract = "Chinese data on the polymorphic metabolism of debrisoquine metoprolol, codeine and mephenytoin were collected and reanalysed using a meta-analysis method. There were no significant differences in the incidences of poor metabolizer (PM) between the separate series of debrisoquine, metoprolol and codeine, which are the three probe drugs reflecting the same enzyme polymorphism. PMs were detected at low frequencies for debrisoquine (1.20{\%}; 95{\%} confidence interval, CI: 0.67-1.98{\%}), metoprolol (0.72{\%}; CI: 0.29-1.49{\%}) and codeine (0.48{\%}, CI: 0.01-2.68{\%}). The overall estimate of PM was 0.95{\%} (CI: 0.60-1.42{\%}) based on the 2427 determinations of all three probe drugs. The overall mean of PM of mephenytoin was 14.32{\%} (12.26-16.38{\%}) in the 1117 subjects. In summary, the present meta-analysis determined the accurate incidences of the genetic deficiency of S-mephenytoin 4'-hydroxylase (cytochrome P450 2C19) and debrisoquine hydroxylase (cytochrome P450 2D6) in Chinese populations.",
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