Genetic polymorphisms within the human Toll-like receptor 2 subfamily

R. I. Tapping, K. O. Omueti, C. M. Johnson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.

Original languageEnglish (US)
Pages (from-to)1445-1448
Number of pages4
JournalBiochemical Society Transactions
Volume35
Issue number6
DOIs
StatePublished - Dec 1 2007

Fingerprint

Toll-Like Receptors
Genetic Polymorphisms
Polymorphism
Immune system
Communicable Diseases
Immune System
Helminths
Pattern recognition
Single Nucleotide Polymorphism
Vertebrates
Nucleotides
Molecules
Incidence
human TLR2 protein

Keywords

  • Infection
  • Innate immunity
  • Pattern recognition
  • Polymorphism
  • Toll-like receptor

ASJC Scopus subject areas

  • Biochemistry

Cite this

Genetic polymorphisms within the human Toll-like receptor 2 subfamily. / Tapping, R. I.; Omueti, K. O.; Johnson, C. M.

In: Biochemical Society Transactions, Vol. 35, No. 6, 01.12.2007, p. 1445-1448.

Research output: Contribution to journalArticle

Tapping, R. I. ; Omueti, K. O. ; Johnson, C. M. / Genetic polymorphisms within the human Toll-like receptor 2 subfamily. In: Biochemical Society Transactions. 2007 ; Vol. 35, No. 6. pp. 1445-1448.
@article{d0410e19abf440e7a97c289617904698,
title = "Genetic polymorphisms within the human Toll-like receptor 2 subfamily",
abstract = "Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.",
keywords = "Infection, Innate immunity, Pattern recognition, Polymorphism, Toll-like receptor",
author = "Tapping, {R. I.} and Omueti, {K. O.} and Johnson, {C. M.}",
year = "2007",
month = "12",
day = "1",
doi = "10.1042/BST0351445",
language = "English (US)",
volume = "35",
pages = "1445--1448",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "6",

}

TY - JOUR

T1 - Genetic polymorphisms within the human Toll-like receptor 2 subfamily

AU - Tapping, R. I.

AU - Omueti, K. O.

AU - Johnson, C. M.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.

AB - Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.

KW - Infection

KW - Innate immunity

KW - Pattern recognition

KW - Polymorphism

KW - Toll-like receptor

UR - http://www.scopus.com/inward/record.url?scp=37749054892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37749054892&partnerID=8YFLogxK

U2 - 10.1042/BST0351445

DO - 10.1042/BST0351445

M3 - Article

VL - 35

SP - 1445

EP - 1448

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 6

ER -