Genetic regulation of somite formation.

A. Rawls, J. Wilson-Rawls, E. N. Olson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Segmentation of the paraxial mesoderm into somites requires a strategy distinct from the division of a preexisting field of cells, as seen in the segmentation of the vertebrate hindbrain into rhombomeres and the formation of the body plan of invertebrates. Each new somite forms from the anterior end of the segmental plate; therefore, the conditions for establishing the anterior-posterior boundary must be re-created prior to the formation of the next somite. It has been established that regulation of this process is native to the anterior end of the segmental plate, however, the components of a genetic pathway are poorly understood. A growing library of candidate genes has been generated from hybridization screens and sequence homology searches, which include cell adhesion molecules, cell surface receptors, growth factors, and transcription factors. With the increasing accessibility of gene knockout technology, many of these genes have been tested for their role in regulating somitogenesis. In this chapter, we will review the significant advances in our understanding of segmentation based on these experiments.

Original languageEnglish (US)
Pages (from-to)131-154
Number of pages24
JournalCurrent Topics in Developmental Biology
Volume47
StatePublished - 2000

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Somites
Rhombencephalon
Gene Knockout Techniques
Cell Adhesion Molecules
Cell Surface Receptors
Mesoderm
Invertebrates
Sequence Homology
Gene Library
Vertebrates
Intercellular Signaling Peptides and Proteins
Transcription Factors
Technology
Genes

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Genetic regulation of somite formation. / Rawls, A.; Wilson-Rawls, J.; Olson, E. N.

In: Current Topics in Developmental Biology, Vol. 47, 2000, p. 131-154.

Research output: Contribution to journalArticle

Rawls, A. ; Wilson-Rawls, J. ; Olson, E. N. / Genetic regulation of somite formation. In: Current Topics in Developmental Biology. 2000 ; Vol. 47. pp. 131-154.
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