Genetic study of the CD36 gene in a French diabetic population

F. Leprêtre, K. J. Linton, C. Lacquemant, V. Vatin, C. Samson, C. Dina, M. Chikri, S. Ali, P. Scherer, K. Séron, F. Vasseur, T. Aitman, P. Froguel

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Objectives: CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein. In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown. Methods: We screened the entire coding sequence of the CD36 gene in 272 individuals and we genotyped both rare and frequent variants in 454 T2D subjects and 221 controls. Results: We detected five mutations, P191P and M247S were only found each in one family and did not segregate with diabetes, the three others (A/C-178 in the promoter, A/G-10 in intron 3 and (GGGTTGAGA) insertion in intron 13) being equally frequent in diabetic subjects and in controls. However, adiponectin levels, a marker for insulin sensitivity, were significantly associated with the -178 A/C promoter variant allele (p = 0.003, p corrected for multiple testing = 0.036), possibly reflecting association with insulin-resistance in the French population. Conclusion: Thus, the -178 A/C SMP promoter mutation in the CD36 gene represents a putative genetic marker for insulin-resistance in the French population, although it does not appear to contribute to the genetic risk for T2D.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalDiabetes and Metabolism
Volume30
Issue number5
DOIs
StatePublished - Nov 2004

Keywords

  • Adiponectin
  • CD36
  • Genetics
  • Insulin-resistance
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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