Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

Xiao Nan Dong; Jian Ying; Yi Wu; Ying Hua Chen

doi:10.1016/j.imlet.2005.04.013

Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

Xiao Nan Dong, Jian Ying, Yi Wu, Ying Hua Chen

Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.

Original language	English (US)
Pages (from-to)	104-107
Number of pages	4
Journal	Immunology Letters
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.04.013
State	Published - Oct 15 2005

Keywords

Genetic variability
Gp41
HIV-1
Neutralizing epitopes
Subtype

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.imlet.2005.04.013

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title = "Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes",

abstract = "Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.",

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AU - Ying, Jian

AU - Wu, Yi

AU - Chen, Ying Hua

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