Abstract
Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 104-107 |
| Number of pages | 4 |
| Journal | Immunology Letters |
| Volume | 101 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 15 2005 |
Keywords
- Genetic variability
- Gp41
- HIV-1
- Neutralizing epitopes
- Subtype
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
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Dong, X. N., Ying, J., Wu, Y., & Chen, Y. H. (2005). Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes. Immunology Letters, 101(1), 104-107. https://doi.org/10.1016/j.imlet.2005.04.013