Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

Xiao Nan Dong; Jian Ying; Yi Wu; Ying Hua Chen

doi:10.1016/j.imlet.2005.04.013

Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

Xiao Nan Dong, Jian Ying, Yi Wu, Ying Hua Chen

Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.

Original language	English (US)
Pages (from-to)	104-107
Number of pages	4
Journal	Immunology Letters
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.04.013
State	Published - Oct 15 2005

Keywords

Genetic variability
Gp41
HIV-1
Neutralizing epitopes
Subtype

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Access to Document

10.1016/j.imlet.2005.04.013

Cite this

@article{4a92e7c7be6747e08aea48ca2c17d94e,

title = "Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes",

abstract = "Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.",

keywords = "Genetic variability, Gp41, HIV-1, Neutralizing epitopes, Subtype",

author = "Dong, {Xiao Nan} and Jian Ying and Yi Wu and Chen, {Ying Hua}",

year = "2005",

month = oct,

day = "15",

doi = "10.1016/j.imlet.2005.04.013",

language = "English (US)",

volume = "101",

pages = "104--107",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

AU - Dong, Xiao Nan

AU - Ying, Jian

AU - Wu, Yi

AU - Chen, Ying Hua

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.

AB - Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.

KW - Genetic variability

KW - Gp41

KW - HIV-1

KW - Neutralizing epitopes

KW - Subtype

UR - http://www.scopus.com/inward/record.url?scp=24744469225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24744469225&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2005.04.013

DO - 10.1016/j.imlet.2005.04.013

M3 - Article

C2 - 15961163

AN - SCOPUS:24744469225

VL - 101

SP - 104

EP - 107

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1

ER -

Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this