Abstract
Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 104-107 |
| Number of pages | 4 |
| Journal | Immunology Letters |
| Volume | 101 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 15 2005 |
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Keywords
- Genetic variability
- Gp41
- HIV-1
- Neutralizing epitopes
- Subtype
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes. / Dong, Xiao Nan; Ying, Jian; Wu, Yi; Chen, Ying Hua.
In: Immunology Letters, Vol. 101, No. 1, 15.10.2005, p. 104-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes
AU - Dong, Xiao Nan
AU - Ying, Jian
AU - Wu, Yi
AU - Chen, Ying Hua
PY - 2005/10/15
Y1 - 2005/10/15
N2 - Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
AB - Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
KW - Genetic variability
KW - Gp41
KW - HIV-1
KW - Neutralizing epitopes
KW - Subtype
UR - http://www.scopus.com/inward/record.url?scp=24744469225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24744469225&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2005.04.013
DO - 10.1016/j.imlet.2005.04.013
M3 - Article
C2 - 15961163
AN - SCOPUS:24744469225
VL - 101
SP - 104
EP - 107
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 1
ER -