Abstract
Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and O group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development.
Original language | English (US) |
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Pages (from-to) | 104-107 |
Number of pages | 4 |
Journal | Immunology Letters |
Volume | 101 |
Issue number | 1 |
DOIs | |
State | Published - Oct 15 2005 |
Keywords
- Genetic variability
- Gp41
- HIV-1
- Neutralizing epitopes
- Subtype
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy