Genetic variants of MnSOD and GPX1 and susceptibility to bladder cancer in a Turkish population

Canan Kucukgergin, Oner Sanli, Akin S. Amasyali, Tzevat Tefik, Sule Seckin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

This study was conducted to investigate the association of genetic polymorphisms in the MnSOD and GPX1 genes with the risk and invasiveness of bladder cancer in a Turkish population. This prospectively designed study enrolled 157 patients with bladder cancer (mean age 63.2 ± 10.86 years) and 224 healthy controls (mean age 61.7 ± 8.39 years). Genotyping of the MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was carried out by PCR-RFLP. No significant difference was found in MnSOD genotype distributions between the controls and the bladder cancer patients. However, the Leu/Leu genotype of GPX1 was associated with a significantly higher risk of bladder cancer than the Pro/Pro genotype. When stratified according to tumor stage, the Leu/Leu genotype of GPX1 was more frequently observed in bladder cancer patients with highstage tumors than those with low-stage tumors. Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. In conclusion, the present study indicates that the GPX1 Pro198Leu polymorphism may be associated with the risk and development of invasive bladder cancer. In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk.

Original languageEnglish (US)
Pages (from-to)1928-1934
Number of pages7
JournalMedical Oncology
Volume29
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • Bladder cancer
  • Glutathione peroxidase 1
  • Manganese superoxide dismutase
  • Polymerase chain reaction-restriction fragment length polymerase analysis
  • Single nucleotide polymorphism
  • Turkish population

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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