Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use

National Birth Defects Prevention Study

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Congenital heart defects (CHDs) are among the most prevalent and serious birth defects, occurring in 8 to 10 of every 1000 live births in the United States. Epidemiologic studies have reported an association between CHDs and maternal smoking, but it remains unknown how genes impact the susceptibility of offspring to CHDs in the presence of maternal tobacco use. Methods: Using data from 403 case- and 219 control-parental triads enrolled in the National Birth Defects Prevention Study between 1998 and 2008, we investigated the association between CHDs and maternal and infant genetic variants involved in the tobacco metabolism and DNA repair pathways among mothers who smoked prenatally. Results: The maternal genotypes of single nucleotide polymorphisms in the excision repair cross-complementation group 1 (ERCC1), poly (ADP-ribose) polymerase 2 (PARP2), and ERCC5 genes were identified to be significantly associated with the occurrence of CHDs in the presence of maternal tobacco use. Our analysis also revealed a moderate association between the infant genotypes of polymorphisms in the O-sialoglycoprotein endopeptidase (OSGEP) gene and increased risk of CHDs among mothers who smoked. Conclusion: Our study provides evidence that maternal and infant polymorphisms within the ERCC1, PARP2, ERCC5, and OSGEP genes are associated with CHD risk in the presence of maternal tobacco use. These results may provide insight into the susceptibility of having a pregnancy affected by CHDs among women who smoke.

Original languageEnglish (US)
Pages (from-to)834-842
Number of pages9
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume103
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Congenital Heart Defects
Tobacco Use
Mothers
DNA Repair
Genes
Genotype
Live Birth
Smoke
Tobacco
Single Nucleotide Polymorphism
Epidemiologic Studies
Smoking
Pregnancy

Keywords

  • Congenital heart defects
  • Genetic variants
  • National birth defects prevention study
  • Single nucleotide polymorphisms
  • Tobacco use

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

Cite this

Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use. / National Birth Defects Prevention Study.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 103, No. 10, 01.10.2015, p. 834-842.

Research output: Contribution to journalArticle

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author = "{National Birth Defects Prevention Study} and Xinyu Tang and Hobbs, {Charlotte A.} and Cleves, {Mario A.} and Erickson, {Stephen W.} and Macleod, {Stewart L.} and Sadia Malik",
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