TY - JOUR
T1 - Genetically-defined metabolic reprogramming in cancer
AU - Mullen, Andrew R.
AU - DeBerardinis, Ralph J.
N1 - Funding Information:
A.R.M. is supported by National Institutes of Health (NIH) Training Grant 5T32GM083831. R.J.D. is supported by grants from the NIH (CA157996), the Cancer Prevention and Research Institute of Texas (HIRP100437 and RP101243), the Robert A. Welch Foundation (I-1733), and the Damon-Runyon Cancer Research Foundation.
PY - 2012/11
Y1 - 2012/11
N2 - Oncogenes and tumor suppressors regulate cell metabolism. Evidence demonstrates that tumorigenic mutations in these genes tend to orchestrate metabolic activity into a platform that promotes cell survival, growth, and proliferation. Recent work has shown that some metabolic enzymes are also mutated in cancer, and that these mutations may influence malignancy directly. Thus, these enzymes seem to function as oncogenes and tumor suppressors, and would appear to be compelling targets for therapeutic intervention. Here, we review several enzymes mutated in cancer - phosphoglycerate dehydrogenase, isocitrate dehydrogenases 1 and 2, succinate dehydrogenase, and fumarate hydratase - and discuss exciting new work that has begun to pull back the curtain on how mutations in these enzymes influence tumorigenesis.
AB - Oncogenes and tumor suppressors regulate cell metabolism. Evidence demonstrates that tumorigenic mutations in these genes tend to orchestrate metabolic activity into a platform that promotes cell survival, growth, and proliferation. Recent work has shown that some metabolic enzymes are also mutated in cancer, and that these mutations may influence malignancy directly. Thus, these enzymes seem to function as oncogenes and tumor suppressors, and would appear to be compelling targets for therapeutic intervention. Here, we review several enzymes mutated in cancer - phosphoglycerate dehydrogenase, isocitrate dehydrogenases 1 and 2, succinate dehydrogenase, and fumarate hydratase - and discuss exciting new work that has begun to pull back the curtain on how mutations in these enzymes influence tumorigenesis.
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U2 - 10.1016/j.tem.2012.06.009
DO - 10.1016/j.tem.2012.06.009
M3 - Review article
C2 - 22858391
AN - SCOPUS:84867139220
SN - 1043-2760
VL - 23
SP - 552
EP - 559
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 11
ER -