Genetics and epigenetics in adult neurogenesis

Jenny Hsieh, Xinyu Zhao

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of “stemness” and commitment to differentiation are tightly controlled by intricate molecular networks. Epigenetic mechanisms, including chromatin remodeling, DNA methylation, and noncoding RNAs (ncRNAs), have profound regulatory roles in mammalian gene expression. Significant advances have been made regarding the dynamic roles of epigenetic modulation and function. It has become evident that epigenetic regulators are key players in neural-stem-cell self-renewal, fate specification, and final maturation of new neurons, therefore, adult neurogenesis. Altered epigenetic regulation can result in a number of neurological and neurodevelopmental disorders. Here, we review recent discoveries that advance our knowledge in epigenetic regulation of mammalian neural stem cells and neurogenesis. Insights from studies of epigenetic gene regulation in neurogenesis may lead to new therapies for the treatment of neurodevelopmental disorders.

Original languageEnglish (US)
Article numbera018911
JournalCold Spring Harbor perspectives in biology
Volume8
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Neurogenesis
Stem cells
Epigenomics
Gene expression
Neural Stem Cells
Untranslated RNA
Neurons
Chromatin
Brain
Modulation
Specifications
Chromatin Assembly and Disassembly
DNA Methylation
Nervous System Diseases
Genetics
Maintenance
Gene Expression
Genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Genetics and epigenetics in adult neurogenesis. / Hsieh, Jenny; Zhao, Xinyu.

In: Cold Spring Harbor perspectives in biology, Vol. 8, No. 6, a018911, 01.06.2016.

Research output: Contribution to journalArticle

Hsieh, Jenny ; Zhao, Xinyu. / Genetics and epigenetics in adult neurogenesis. In: Cold Spring Harbor perspectives in biology. 2016 ; Vol. 8, No. 6.
@article{89019d9fb6894cbfad2ff1208f56051a,
title = "Genetics and epigenetics in adult neurogenesis",
abstract = "The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of “stemness” and commitment to differentiation are tightly controlled by intricate molecular networks. Epigenetic mechanisms, including chromatin remodeling, DNA methylation, and noncoding RNAs (ncRNAs), have profound regulatory roles in mammalian gene expression. Significant advances have been made regarding the dynamic roles of epigenetic modulation and function. It has become evident that epigenetic regulators are key players in neural-stem-cell self-renewal, fate specification, and final maturation of new neurons, therefore, adult neurogenesis. Altered epigenetic regulation can result in a number of neurological and neurodevelopmental disorders. Here, we review recent discoveries that advance our knowledge in epigenetic regulation of mammalian neural stem cells and neurogenesis. Insights from studies of epigenetic gene regulation in neurogenesis may lead to new therapies for the treatment of neurodevelopmental disorders.",
author = "Jenny Hsieh and Xinyu Zhao",
year = "2016",
month = "6",
day = "1",
doi = "10.1101/cshperspect.a018911",
language = "English (US)",
volume = "8",
journal = "Cold Spring Harbor perspectives in biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "6",

}

TY - JOUR

T1 - Genetics and epigenetics in adult neurogenesis

AU - Hsieh, Jenny

AU - Zhao, Xinyu

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of “stemness” and commitment to differentiation are tightly controlled by intricate molecular networks. Epigenetic mechanisms, including chromatin remodeling, DNA methylation, and noncoding RNAs (ncRNAs), have profound regulatory roles in mammalian gene expression. Significant advances have been made regarding the dynamic roles of epigenetic modulation and function. It has become evident that epigenetic regulators are key players in neural-stem-cell self-renewal, fate specification, and final maturation of new neurons, therefore, adult neurogenesis. Altered epigenetic regulation can result in a number of neurological and neurodevelopmental disorders. Here, we review recent discoveries that advance our knowledge in epigenetic regulation of mammalian neural stem cells and neurogenesis. Insights from studies of epigenetic gene regulation in neurogenesis may lead to new therapies for the treatment of neurodevelopmental disorders.

AB - The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of “stemness” and commitment to differentiation are tightly controlled by intricate molecular networks. Epigenetic mechanisms, including chromatin remodeling, DNA methylation, and noncoding RNAs (ncRNAs), have profound regulatory roles in mammalian gene expression. Significant advances have been made regarding the dynamic roles of epigenetic modulation and function. It has become evident that epigenetic regulators are key players in neural-stem-cell self-renewal, fate specification, and final maturation of new neurons, therefore, adult neurogenesis. Altered epigenetic regulation can result in a number of neurological and neurodevelopmental disorders. Here, we review recent discoveries that advance our knowledge in epigenetic regulation of mammalian neural stem cells and neurogenesis. Insights from studies of epigenetic gene regulation in neurogenesis may lead to new therapies for the treatment of neurodevelopmental disorders.

UR - http://www.scopus.com/inward/record.url?scp=84973161212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973161212&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a018911

DO - 10.1101/cshperspect.a018911

M3 - Article

C2 - 27143699

AN - SCOPUS:84973161212

VL - 8

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

SN - 1943-0264

IS - 6

M1 - a018911

ER -