Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary

Elena I. Ivleva, David W. Morris, Amanda F. Moates, Trisha Suppes, Gunvant K. Thaker, Carol A. Tamminga

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping symptom dimensions, neurophysiology, genetics and treatment responses. Recent large scale genetic studies have produced inconsistent findings and exposed an urgent need for re-thinking phenomenology-based approach in psychiatric research. Epidemiological, linkage and molecular genetic studies, as well as studies in intermediate phenotypes (neurocognitive, neurophysiological and anatomical imaging) in schizophrenia and bipolar disorders are reviewed in order to support a dimensional conceptualization of psychosis. Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed.

Original languageEnglish (US)
Pages (from-to)897-921
Number of pages25
JournalNeuroscience and Biobehavioral Reviews
Volume34
Issue number6
DOIs
StatePublished - May 2010

Fingerprint

Bipolar Disorder
Psychotic Disorders
Schizophrenia
Phenotype
Psychotic Affective Disorders
Genetic Research
Neurophysiology
Psychiatry
Molecular Biology
Research

Keywords

  • Bipolar disorder
  • Genetics
  • Imaging
  • Intermediate phenotypes
  • Neurocognition
  • Neurophysiology
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary. / Ivleva, Elena I.; Morris, David W.; Moates, Amanda F.; Suppes, Trisha; Thaker, Gunvant K.; Tamminga, Carol A.

In: Neuroscience and Biobehavioral Reviews, Vol. 34, No. 6, 05.2010, p. 897-921.

Research output: Contribution to journalArticle

@article{75cbb926a1524454a321404be34fc039,
title = "Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary",
abstract = "Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping symptom dimensions, neurophysiology, genetics and treatment responses. Recent large scale genetic studies have produced inconsistent findings and exposed an urgent need for re-thinking phenomenology-based approach in psychiatric research. Epidemiological, linkage and molecular genetic studies, as well as studies in intermediate phenotypes (neurocognitive, neurophysiological and anatomical imaging) in schizophrenia and bipolar disorders are reviewed in order to support a dimensional conceptualization of psychosis. Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed.",
keywords = "Bipolar disorder, Genetics, Imaging, Intermediate phenotypes, Neurocognition, Neurophysiology, Psychosis, Schizophrenia",
author = "Ivleva, {Elena I.} and Morris, {David W.} and Moates, {Amanda F.} and Trisha Suppes and Thaker, {Gunvant K.} and Tamminga, {Carol A.}",
year = "2010",
month = "5",
doi = "10.1016/j.neubiorev.2009.11.022",
language = "English (US)",
volume = "34",
pages = "897--921",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary

AU - Ivleva, Elena I.

AU - Morris, David W.

AU - Moates, Amanda F.

AU - Suppes, Trisha

AU - Thaker, Gunvant K.

AU - Tamminga, Carol A.

PY - 2010/5

Y1 - 2010/5

N2 - Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping symptom dimensions, neurophysiology, genetics and treatment responses. Recent large scale genetic studies have produced inconsistent findings and exposed an urgent need for re-thinking phenomenology-based approach in psychiatric research. Epidemiological, linkage and molecular genetic studies, as well as studies in intermediate phenotypes (neurocognitive, neurophysiological and anatomical imaging) in schizophrenia and bipolar disorders are reviewed in order to support a dimensional conceptualization of psychosis. Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed.

AB - Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an ongoing controversy. Although Kraepelinian subtyping of psychosis was historically beneficial, modern genetic and neurophysiological studies do not support dichotomous conceptualization of psychosis. Evidence suggests that schizophrenia and bipolar disorder rather present a clinical continuum with partially overlapping symptom dimensions, neurophysiology, genetics and treatment responses. Recent large scale genetic studies have produced inconsistent findings and exposed an urgent need for re-thinking phenomenology-based approach in psychiatric research. Epidemiological, linkage and molecular genetic studies, as well as studies in intermediate phenotypes (neurocognitive, neurophysiological and anatomical imaging) in schizophrenia and bipolar disorders are reviewed in order to support a dimensional conceptualization of psychosis. Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed.

KW - Bipolar disorder

KW - Genetics

KW - Imaging

KW - Intermediate phenotypes

KW - Neurocognition

KW - Neurophysiology

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=77950690252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950690252&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2009.11.022

DO - 10.1016/j.neubiorev.2009.11.022

M3 - Article

C2 - 19954751

AN - SCOPUS:77950690252

VL - 34

SP - 897

EP - 921

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

IS - 6

ER -