Genetics, metabolism and atherogenicity of LP(A)

Research output: Contribution to journalArticle

Abstract

Lipoprotein(a) [Lp(a)J is composed of a panicle of low density lipoprotein (LDL) to which is attached a large, highly polymorphic glycoprotein called apolipoprotein(a) [apo(a)]. In humans high plasma levels of Lp(a) are associated with an increased risk of atherosclerosis Plasma levels of Lp(a) vary over a 1000-fold range and are largely determined by sequence differences in the apo(a) gene. Most species do not express Lp(a), which has limited our ability to probe the mechanistic link between Lp(a) and atherosclerosis To produce an animal model in which to study the metabolism and the atherogenic effects of Lp(a), transgenic mice expressing the both the human apo(a) and apoB-IOO genes were developed Using these animals, inconsistent results have been reported by different laboratories regarding the association between apo(a) or Lp(a) and atherosclerosis This lecture will focus on recent insights into the metabolism of apo(a), which may provide clues as to source for the variable expression of atherosclerosis in these transgenic mice.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number9
StatePublished - 1997

Fingerprint

Apoprotein(a)
apolipoproteins
Metabolism
atherosclerosis
Atherosclerosis
metabolism
Transgenic Mice
Animals
Genes
genetically modified organisms
Plasmas
Lipoprotein(a)
mice
Apolipoproteins B
low density lipoprotein
LDL Lipoproteins
lipoproteins
glycoproteins
Glycoproteins
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Genetics, metabolism and atherogenicity of LP(A). / Hobbs, Helen H.

In: FASEB Journal, Vol. 11, No. 9, 1997.

Research output: Contribution to journalArticle

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