Abstract
Adolescent idiopathic scoliosis (AIS) is the most common pediatric musculoskeletal disorder, affecting about 2-3% of the children worldwide. The underlying etiology of AIS has proven elusive, in part due to the lack of appropriate animal models and systems that would enable laboratory-based research. In contrast, genetic studies in patient populations have highlighted several candidate genes suggesting possible neuromuscular origins. Developing genetically defined animal models to facilitate hypothesis testing is a high priority for ongoing AIS research. Continued gene discovery efforts supported by next-generation genomic platforms will yield exciting new insights into AIS disease pathways, opening the prospect for pharmaceutical interventions.
Original language | English (US) |
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Pages (from-to) | 9-15 |
Number of pages | 7 |
Journal | Seminars in Spine Surgery |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2015 |
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine