Genetics of adolescent idiopathic scoliosis

Nandina Paria, Carol A. Wise

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Adolescent idiopathic scoliosis (AIS) is the most common pediatric musculoskeletal disorder, affecting about 2-3% of the children worldwide. The underlying etiology of AIS has proven elusive, in part due to the lack of appropriate animal models and systems that would enable laboratory-based research. In contrast, genetic studies in patient populations have highlighted several candidate genes suggesting possible neuromuscular origins. Developing genetically defined animal models to facilitate hypothesis testing is a high priority for ongoing AIS research. Continued gene discovery efforts supported by next-generation genomic platforms will yield exciting new insights into AIS disease pathways, opening the prospect for pharmaceutical interventions.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalSeminars in Spine Surgery
Volume27
Issue number1
DOIs
StatePublished - Mar 1 2015

    Fingerprint

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this