Abstract
Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcγRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of congenic mice, bearing in a normal genetic background one single disease-associated locus, greatly improved our understanding of the mechanisms mediating the genetic contribution to the disease. In the future, the identification of disease-associated genes will open new perspectives for the development of more targeted therapies of lupus nephritis.
Original language | English (US) |
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Pages (from-to) | 2-12 |
Number of pages | 11 |
Journal | Lupus |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 21 2005 |
Keywords
- Congenic mice
- Genetics
- Lupus
- Mouse models
- SLE
- Susceptibility genes
ASJC Scopus subject areas
- Rheumatology