Genetics of lupus nephritis

B. R. Lauwerys, E. K. Wakeland

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcγRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of congenic mice, bearing in a normal genetic background one single disease-associated locus, greatly improved our understanding of the mechanisms mediating the genetic contribution to the disease. In the future, the identification of disease-associated genes will open new perspectives for the development of more targeted therapies of lupus nephritis.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalLupus
Volume14
Issue number1
DOIs
StatePublished - Feb 21 2005

Keywords

  • Congenic mice
  • Genetics
  • Lupus
  • Mouse models
  • SLE
  • Susceptibility genes

ASJC Scopus subject areas

  • Rheumatology

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