Genomic analyses of hormone signaling and gene regulation

Edwin Cheung, W. Lee Kraus

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

Many cellular signaling pathways ultimately control specific patterns of gene expression in the nucleus through a variety of signal-regulated transcription factors (TFs), including nuclear hormone receptors (NRs). The advent of genomic technologies for examining signal-regulated transcriptional responses and TF binding on a genomic scale has dramatically increased our understanding of the cellular programs that control hormonal signaling and gene regulation. Studies of TFs, especially NRs, using genomic approaches have revealed novel and unexpected features of hormone-regulated transcription, and a global view is beginning to emerge. In this review, we discuss the genomic methodologies that have been applied to the study of hormone-regulated gene expression, the results that have been obtained from using them, and the future prospects for these approaches. Given the wealth of information about hormone-dependent gene regulation by NRs, we have focused this review on the knowledge gained from genomic studies of their function.

Original languageEnglish (US)
Pages (from-to)191-218
Number of pages28
JournalAnnual Review of Physiology
Volume72
DOIs
StatePublished - Mar 17 2009

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Keywords

  • Bioinformatics
  • Chromatin immunoprecipitation
  • Hormone response element
  • Massively parallel sequencing
  • Nuclear receptor
  • Transcription factor

ASJC Scopus subject areas

  • Physiology

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