Genomic Differences Between “Primary” and “Secondary” Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy [Figure presented]

Eugene J. Pietzak, Emily C. Zabor, Aditya Bagrodia, Joshua Armenia, Wenhuo Hu, Ahmet Zehir, Samuel Funt, Francois Audenet, David Barron, Noelia Maamouri, Qiang Li, Min Yuen Teo, Maria E. Arcila, Michael F. Berger, Nikolaus Schultz, Guido Dalbagni, Harry W. Herr, Dean F. Bajorin, Jonathan E. Rosenberg, Hikmat Al-AhmadieBernard H. Bochner, David B. Solit, Gopa Iyer

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Patients with secondary muscle-invasive bladder cancer (MIBC) treated with neoadjuvant chemotherapy had worse clinical outcomes than patients treated similarly with primary MIBC. These contrasting clinical outcomes may have resulted from differing rates of cisplatin-sensitizing ERCC2 mutations that were enriched in primary MIBC.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalEuropean urology
Volume75
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • Bladder cancer
  • ERCC2
  • Muscle-invasive bladder cancer
  • Neoadjuvant chemotherapy
  • Non–muscle-invasive bladder cancer
  • Radical cystectomy

ASJC Scopus subject areas

  • Urology

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    Pietzak, E. J., Zabor, E. C., Bagrodia, A., Armenia, J., Hu, W., Zehir, A., Funt, S., Audenet, F., Barron, D., Maamouri, N., Li, Q., Teo, M. Y., Arcila, M. E., Berger, M. F., Schultz, N., Dalbagni, G., Herr, H. W., Bajorin, D. F., Rosenberg, J. E., ... Iyer, G. (2019). Genomic Differences Between “Primary” and “Secondary” Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy [Figure presented]. European urology, 75(2), 231-239. https://doi.org/10.1016/j.eururo.2018.09.002