Genomic evolution of the distal Mhc class I region on mouse Chr 17

Masayasu Yoshino, Hong Xiao, Elsy P. Jones, Attila Kumánovics, Claire Amadou, Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 5-Mb YAC contig, partly supplemented with BAC contigs, was created From the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M legion is rich in L1 repeats. implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.

Original languageEnglish (US)
Pages (from-to)141-148
Number of pages8
JournalHereditas
Volume127
Issue number1-2
StatePublished - 1997

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MHC Class I Genes
Synteny
Chromosome Breakage
Gene Order

ASJC Scopus subject areas

  • Genetics

Cite this

Yoshino, M., Xiao, H., Jones, E. P., Kumánovics, A., Amadou, C., & Fischer Lindahl, K. (1997). Genomic evolution of the distal Mhc class I region on mouse Chr 17. Hereditas, 127(1-2), 141-148.

Genomic evolution of the distal Mhc class I region on mouse Chr 17. / Yoshino, Masayasu; Xiao, Hong; Jones, Elsy P.; Kumánovics, Attila; Amadou, Claire; Fischer Lindahl, Kirsten.

In: Hereditas, Vol. 127, No. 1-2, 1997, p. 141-148.

Research output: Contribution to journalArticle

Yoshino, M, Xiao, H, Jones, EP, Kumánovics, A, Amadou, C & Fischer Lindahl, K 1997, 'Genomic evolution of the distal Mhc class I region on mouse Chr 17', Hereditas, vol. 127, no. 1-2, pp. 141-148.
Yoshino M, Xiao H, Jones EP, Kumánovics A, Amadou C, Fischer Lindahl K. Genomic evolution of the distal Mhc class I region on mouse Chr 17. Hereditas. 1997;127(1-2):141-148.
Yoshino, Masayasu ; Xiao, Hong ; Jones, Elsy P. ; Kumánovics, Attila ; Amadou, Claire ; Fischer Lindahl, Kirsten. / Genomic evolution of the distal Mhc class I region on mouse Chr 17. In: Hereditas. 1997 ; Vol. 127, No. 1-2. pp. 141-148.
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