Abstract
A 5-Mb YAC contig, partly supplemented with BAC contigs, was created From the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M legion is rich in L1 repeats. implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.
Original language | English (US) |
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Pages (from-to) | 141-148 |
Number of pages | 8 |
Journal | Hereditas |
Volume | 127 |
Issue number | 1-2 |
DOIs | |
State | Published - 1997 |
ASJC Scopus subject areas
- Genetics