TY - JOUR
T1 - Genomic views of transcriptional enhancers
T2 - Essential determinants of cellular identity and activity-dependent responses in the CNS
AU - Gray, Jesse M.
AU - Kim, Tae Kyung
AU - West, Anne E.
AU - Nord, Alex S.
AU - Markenscoff-Papadimitriou, Eirene
AU - Lomvardas, Stavros
N1 - Publisher Copyright:
© 2015 the authors.
PY - 2015/10/14
Y1 - 2015/10/14
N2 - Sprinkled throughout the genome are a million regulatory sequences called transcriptional enhancers that activate gene promoters in the right cells, at the right time. Enhancers endow the brain with its incredible diversity of cell types and also translate neural activity into gene induction. Thanks to rapid advances in genomic technologies, it is now possible to identify thousands of enhancers rapidly, test their transcriptional function en masse, and address their neurobiological functions via genome editing. Enhancers also promise to be a great technological opportunity for neuroscience, offering the potential for cell-type-specific genetic labeling and manipulation without the need for transgenesis. The objective of this review and the accompanying 2015 SfN mini-symposium is to highlight the use of new and emerging genomic technologies to probe enhancer function in the nervous system.
AB - Sprinkled throughout the genome are a million regulatory sequences called transcriptional enhancers that activate gene promoters in the right cells, at the right time. Enhancers endow the brain with its incredible diversity of cell types and also translate neural activity into gene induction. Thanks to rapid advances in genomic technologies, it is now possible to identify thousands of enhancers rapidly, test their transcriptional function en masse, and address their neurobiological functions via genome editing. Enhancers also promise to be a great technological opportunity for neuroscience, offering the potential for cell-type-specific genetic labeling and manipulation without the need for transgenesis. The objective of this review and the accompanying 2015 SfN mini-symposium is to highlight the use of new and emerging genomic technologies to probe enhancer function in the nervous system.
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U2 - 10.1523/JNEUROSCI.2622-15.2015
DO - 10.1523/JNEUROSCI.2622-15.2015
M3 - Review article
C2 - 26468181
AN - SCOPUS:84944621606
SN - 0270-6474
VL - 35
SP - 13819
EP - 13826
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 41
ER -