Abstract
Microarray-based comparisons of long-lived and normal mouse strains represent a promising approach for dissecting the basis of lifespan extension in higher organisms. Recently, Boylston et al. (2006) generated a genome-wide data set that allowed expression levels of Snell (Pit1dw/dw) and Ames (Prop1df/df) long-lived mice to be compared with age-matched control mice across different ages (6-24 months). Longevity-associated genes were identified as those genes exhibiting differential expression between long-lived and normal mice at every age examined. In this communication, an alternative approach to identifying longevity-associated genes is suggested and applied to the data sets considered by Boylston et al. (2006). Longevity-associated genes are defined as those exhibiting significant genotype-by-age interaction with respect to expression levels of long-lived and normal mice, and a total of 63 longevity-associated genes are identified. This approach may lend greater confidence to the inference that expression of identified genes specifically underlies aging differences between long-lived and normal genotypes.
Original language | English (US) |
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Pages (from-to) | 97-102 |
Number of pages | 6 |
Journal | Age |
Volume | 29 |
Issue number | 2-3 |
DOIs | |
State | Published - Sep 2007 |
Externally published | Yes |
Keywords
- Aging
- Ames
- Dwarf
- Lifespan
- Microarray
- Pit1
- Prop1
- Snell
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology