Genotypic Characteristics of Resistant Tumors to Pre-Operative Ionizing Radiation in Rectal Cancer

Zeeshan Ramzan, Ammar B. Nassri, Sergio Huerta

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Due to a wide range of clinical response in patients undergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients receiving the same form of treatment. Despite extensive research in this field, the exact mechanisms still remain elusive. Data raging from DNA-repair to specific molecules leading to cell survival as well as resistance to apoptosis have been investigated. Individually, or in combination, there is no single pathway that has become clinically applicable to date. In the following review, we describe the current status of various pathways that might lead to resistance to the therapeutic applications of ionizing radiation in rectal cancer.

Original languageEnglish (US)
Pages (from-to)194-210
Number of pages17
JournalWorld Journal of Gastrointestinal Oncology
Volume6
Issue number7
DOIs
StatePublished - Jul 15 2014

Keywords

  • Angiogenesis
  • Apoptosis
  • Complete pathological response
  • DNA double-strand break
  • DNA-PKcs
  • Ionizing radiation
  • Ku proteins
  • Non-homologous end-joining pathway
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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