Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells

B. R. Stanton, S. W. Reid, L. F. Parada

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

Original languageEnglish (US)
Pages (from-to)6755-6758
Number of pages4
JournalMolecular and cellular biology
Volume10
Issue number12
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells'. Together they form a unique fingerprint.

Cite this