Abstract
We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.
Original language | English (US) |
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Pages (from-to) | 6755-6758 |
Number of pages | 4 |
Journal | Molecular and cellular biology |
Volume | 10 |
Issue number | 12 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology