Ghrelin

T. D. Müller, R. Nogueiras, M. L. Andermann, Z. B. Andrews, S. D. Anker, J. Argente, R. L. Batterham, S. C. Benoit, C. Y. Bowers, F. Broglio, F. F. Casanueva, D. D'Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P. A. Cole, M. Cowley, D. E. Cummings, A. Dagher, S. DianoS. L. Dickson, C. Diéguez, R. Granata, H. J. Grill, K. Grove, K. M. Habegger, K. Heppner, M. L. Heiman, L. Holsen, B. Holst, A. Inui, J. O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C. W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P. T. Pfluger, T. W. Schwartz, R. J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M. O. Thorner, A. J. van der Lely, L. H T van der Ploeg, J. M. Zigman, M. Kojima, K. Kangawa, R. G. Smith, T. Horvath, M. H. Tschöp

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original languageEnglish (US)
Pages (from-to)437-460
Number of pages24
JournalMolecular Metabolism
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Ghrelin
Ghrelin Receptor
Gastrointestinal Hormones
Peptide Hormones
Gastric Acid
Reward
Energy Metabolism
Sleep
Learning
Hormones
Ligands
Glucose

Keywords

  • Ghrelin
  • Growth hormone segretagogue receptor

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., ... Tschöp, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

Ghrelin. / Müller, T. D.; Nogueiras, R.; Andermann, M. L.; Andrews, Z. B.; Anker, S. D.; Argente, J.; Batterham, R. L.; Benoit, S. C.; Bowers, C. Y.; Broglio, F.; Casanueva, F. F.; D'Alessio, D.; Depoortere, I.; Geliebter, A.; Ghigo, E.; Cole, P. A.; Cowley, M.; Cummings, D. E.; Dagher, A.; Diano, S.; Dickson, S. L.; Diéguez, C.; Granata, R.; Grill, H. J.; Grove, K.; Habegger, K. M.; Heppner, K.; Heiman, M. L.; Holsen, L.; Holst, B.; Inui, A.; Jansson, J. O.; Kirchner, H.; Korbonits, M.; Laferrère, B.; LeRoux, C. W.; Lopez, M.; Morin, S.; Nakazato, M.; Nass, R.; Perez-Tilve, D.; Pfluger, P. T.; Schwartz, T. W.; Seeley, R. J.; Sleeman, M.; Sun, Y.; Sussel, L.; Tong, J.; Thorner, M. O.; van der Lely, A. J.; van der Ploeg, L. H T; Zigman, J. M.; Kojima, M.; Kangawa, K.; Smith, R. G.; Horvath, T.; Tschöp, M. H.

In: Molecular Metabolism, Vol. 4, No. 6, 01.06.2015, p. 437-460.

Research output: Contribution to journalArticle

Müller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Diéguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO, van der Lely, AJ, van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, T & Tschöp, MH 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437-460. https://doi.org/10.1016/j.molmet.2015.03.005
Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J et al. Ghrelin. Molecular Metabolism. 2015 Jun 1;4(6):437-460. https://doi.org/10.1016/j.molmet.2015.03.005
Müller, T. D. ; Nogueiras, R. ; Andermann, M. L. ; Andrews, Z. B. ; Anker, S. D. ; Argente, J. ; Batterham, R. L. ; Benoit, S. C. ; Bowers, C. Y. ; Broglio, F. ; Casanueva, F. F. ; D'Alessio, D. ; Depoortere, I. ; Geliebter, A. ; Ghigo, E. ; Cole, P. A. ; Cowley, M. ; Cummings, D. E. ; Dagher, A. ; Diano, S. ; Dickson, S. L. ; Diéguez, C. ; Granata, R. ; Grill, H. J. ; Grove, K. ; Habegger, K. M. ; Heppner, K. ; Heiman, M. L. ; Holsen, L. ; Holst, B. ; Inui, A. ; Jansson, J. O. ; Kirchner, H. ; Korbonits, M. ; Laferrère, B. ; LeRoux, C. W. ; Lopez, M. ; Morin, S. ; Nakazato, M. ; Nass, R. ; Perez-Tilve, D. ; Pfluger, P. T. ; Schwartz, T. W. ; Seeley, R. J. ; Sleeman, M. ; Sun, Y. ; Sussel, L. ; Tong, J. ; Thorner, M. O. ; van der Lely, A. J. ; van der Ploeg, L. H T ; Zigman, J. M. ; Kojima, M. ; Kangawa, K. ; Smith, R. G. ; Horvath, T. ; Tschöp, M. H. / Ghrelin. In: Molecular Metabolism. 2015 ; Vol. 4, No. 6. pp. 437-460.
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abstract = "The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",
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T1 - Ghrelin

AU - Müller, T. D.

AU - Nogueiras, R.

AU - Andermann, M. L.

AU - Andrews, Z. B.

AU - Anker, S. D.

AU - Argente, J.

AU - Batterham, R. L.

AU - Benoit, S. C.

AU - Bowers, C. Y.

AU - Broglio, F.

AU - Casanueva, F. F.

AU - D'Alessio, D.

AU - Depoortere, I.

AU - Geliebter, A.

AU - Ghigo, E.

AU - Cole, P. A.

AU - Cowley, M.

AU - Cummings, D. E.

AU - Dagher, A.

AU - Diano, S.

AU - Dickson, S. L.

AU - Diéguez, C.

AU - Granata, R.

AU - Grill, H. J.

AU - Grove, K.

AU - Habegger, K. M.

AU - Heppner, K.

AU - Heiman, M. L.

AU - Holsen, L.

AU - Holst, B.

AU - Inui, A.

AU - Jansson, J. O.

AU - Kirchner, H.

AU - Korbonits, M.

AU - Laferrère, B.

AU - LeRoux, C. W.

AU - Lopez, M.

AU - Morin, S.

AU - Nakazato, M.

AU - Nass, R.

AU - Perez-Tilve, D.

AU - Pfluger, P. T.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Sleeman, M.

AU - Sun, Y.

AU - Sussel, L.

AU - Tong, J.

AU - Thorner, M. O.

AU - van der Lely, A. J.

AU - van der Ploeg, L. H T

AU - Zigman, J. M.

AU - Kojima, M.

AU - Kangawa, K.

AU - Smith, R. G.

AU - Horvath, T.

AU - Tschöp, M. H.

PY - 2015/6/1

Y1 - 2015/6/1

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AB - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

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