Ginseng saponins in different parts of Panax vietnamensis

Thi Hong Van Le, Gwang Jin Lee, Huynh Kim Long Vu, Sung Won Kwon, Ngoc Khoi Nguyen, Jeong Hill Park, Minh Duc Nguyen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chemical and pharmacological studies of Panax vietnamensis (Vietnamese ginseng; VG) have been reported since its discovery in 1973. However, the content of each saponin in different parts of VG has not been reported. In this study, 17 ginsenosides in the different underground parts of P. vietnamensis were analyzed by HPLC/evaporative light scattering detector (ELSD). Their contents in the dried rhizome, radix, and fine roots were 195, 156, and 139 mg/g, respectively, which were extremely high compared to other Panax species. The content of protopanaxatriol (PPT)-type saponins were not much different among underground parts; however, the content of protopanaxadiol (PPD)- and ocotillol (OCT)-type saponins were greatly different. It is noteworthy that the ginsenoside pattern in the fine roots is different from other underground parts. In particular, despite the content of PPD-type saponins being the highest in the fine roots, which is similar to other Panax species, the total content of saponins was the lowest in the fine roots, which is different from other Panax species. The ratios of PPT : PPD : OCT-type saponins were 1 : 1.7 : 7.8, 1 : 1.6 : 5.5, and 1 : 4.8 : 3.3 for the rhizome, radix, and fine roots, respectively. OCT-type saponins accounted for 36-75% of total saponins and contributed mostly to the difference in the total saponin content of each part.

Original languageEnglish (US)
Pages (from-to)950-954
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume63
Issue number11
StatePublished - Nov 1 2015

Fingerprint

Panax
Saponins
Ginsenosides
Rhizome
Light scattering
High Pressure Liquid Chromatography
Pharmacology
Detectors
Light

Keywords

  • Different part
  • Ginsenoside
  • Ocotillol saponin
  • Panax vietnamensis
  • Vietnamese ginseng

ASJC Scopus subject areas

  • Drug Discovery
  • Chemistry(all)

Cite this

Van Le, T. H., Lee, G. J., Vu, H. K. L., Kwon, S. W., Nguyen, N. K., Park, J. H., & Nguyen, M. D. (2015). Ginseng saponins in different parts of Panax vietnamensis. Chemical and Pharmaceutical Bulletin, 63(11), 950-954.

Ginseng saponins in different parts of Panax vietnamensis. / Van Le, Thi Hong; Lee, Gwang Jin; Vu, Huynh Kim Long; Kwon, Sung Won; Nguyen, Ngoc Khoi; Park, Jeong Hill; Nguyen, Minh Duc.

In: Chemical and Pharmaceutical Bulletin, Vol. 63, No. 11, 01.11.2015, p. 950-954.

Research output: Contribution to journalArticle

Van Le, TH, Lee, GJ, Vu, HKL, Kwon, SW, Nguyen, NK, Park, JH & Nguyen, MD 2015, 'Ginseng saponins in different parts of Panax vietnamensis', Chemical and Pharmaceutical Bulletin, vol. 63, no. 11, pp. 950-954.
Van Le TH, Lee GJ, Vu HKL, Kwon SW, Nguyen NK, Park JH et al. Ginseng saponins in different parts of Panax vietnamensis. Chemical and Pharmaceutical Bulletin. 2015 Nov 1;63(11):950-954.
Van Le, Thi Hong ; Lee, Gwang Jin ; Vu, Huynh Kim Long ; Kwon, Sung Won ; Nguyen, Ngoc Khoi ; Park, Jeong Hill ; Nguyen, Minh Duc. / Ginseng saponins in different parts of Panax vietnamensis. In: Chemical and Pharmaceutical Bulletin. 2015 ; Vol. 63, No. 11. pp. 950-954.
@article{2acf77b365814a388c71f76c8d951425,
title = "Ginseng saponins in different parts of Panax vietnamensis",
abstract = "Chemical and pharmacological studies of Panax vietnamensis (Vietnamese ginseng; VG) have been reported since its discovery in 1973. However, the content of each saponin in different parts of VG has not been reported. In this study, 17 ginsenosides in the different underground parts of P. vietnamensis were analyzed by HPLC/evaporative light scattering detector (ELSD). Their contents in the dried rhizome, radix, and fine roots were 195, 156, and 139 mg/g, respectively, which were extremely high compared to other Panax species. The content of protopanaxatriol (PPT)-type saponins were not much different among underground parts; however, the content of protopanaxadiol (PPD)- and ocotillol (OCT)-type saponins were greatly different. It is noteworthy that the ginsenoside pattern in the fine roots is different from other underground parts. In particular, despite the content of PPD-type saponins being the highest in the fine roots, which is similar to other Panax species, the total content of saponins was the lowest in the fine roots, which is different from other Panax species. The ratios of PPT : PPD : OCT-type saponins were 1 : 1.7 : 7.8, 1 : 1.6 : 5.5, and 1 : 4.8 : 3.3 for the rhizome, radix, and fine roots, respectively. OCT-type saponins accounted for 36-75{\%} of total saponins and contributed mostly to the difference in the total saponin content of each part.",
keywords = "Different part, Ginsenoside, Ocotillol saponin, Panax vietnamensis, Vietnamese ginseng",
author = "{Van Le}, {Thi Hong} and Lee, {Gwang Jin} and Vu, {Huynh Kim Long} and Kwon, {Sung Won} and Nguyen, {Ngoc Khoi} and Park, {Jeong Hill} and Nguyen, {Minh Duc}",
year = "2015",
month = "11",
day = "1",
language = "English (US)",
volume = "63",
pages = "950--954",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "11",

}

TY - JOUR

T1 - Ginseng saponins in different parts of Panax vietnamensis

AU - Van Le, Thi Hong

AU - Lee, Gwang Jin

AU - Vu, Huynh Kim Long

AU - Kwon, Sung Won

AU - Nguyen, Ngoc Khoi

AU - Park, Jeong Hill

AU - Nguyen, Minh Duc

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Chemical and pharmacological studies of Panax vietnamensis (Vietnamese ginseng; VG) have been reported since its discovery in 1973. However, the content of each saponin in different parts of VG has not been reported. In this study, 17 ginsenosides in the different underground parts of P. vietnamensis were analyzed by HPLC/evaporative light scattering detector (ELSD). Their contents in the dried rhizome, radix, and fine roots were 195, 156, and 139 mg/g, respectively, which were extremely high compared to other Panax species. The content of protopanaxatriol (PPT)-type saponins were not much different among underground parts; however, the content of protopanaxadiol (PPD)- and ocotillol (OCT)-type saponins were greatly different. It is noteworthy that the ginsenoside pattern in the fine roots is different from other underground parts. In particular, despite the content of PPD-type saponins being the highest in the fine roots, which is similar to other Panax species, the total content of saponins was the lowest in the fine roots, which is different from other Panax species. The ratios of PPT : PPD : OCT-type saponins were 1 : 1.7 : 7.8, 1 : 1.6 : 5.5, and 1 : 4.8 : 3.3 for the rhizome, radix, and fine roots, respectively. OCT-type saponins accounted for 36-75% of total saponins and contributed mostly to the difference in the total saponin content of each part.

AB - Chemical and pharmacological studies of Panax vietnamensis (Vietnamese ginseng; VG) have been reported since its discovery in 1973. However, the content of each saponin in different parts of VG has not been reported. In this study, 17 ginsenosides in the different underground parts of P. vietnamensis were analyzed by HPLC/evaporative light scattering detector (ELSD). Their contents in the dried rhizome, radix, and fine roots were 195, 156, and 139 mg/g, respectively, which were extremely high compared to other Panax species. The content of protopanaxatriol (PPT)-type saponins were not much different among underground parts; however, the content of protopanaxadiol (PPD)- and ocotillol (OCT)-type saponins were greatly different. It is noteworthy that the ginsenoside pattern in the fine roots is different from other underground parts. In particular, despite the content of PPD-type saponins being the highest in the fine roots, which is similar to other Panax species, the total content of saponins was the lowest in the fine roots, which is different from other Panax species. The ratios of PPT : PPD : OCT-type saponins were 1 : 1.7 : 7.8, 1 : 1.6 : 5.5, and 1 : 4.8 : 3.3 for the rhizome, radix, and fine roots, respectively. OCT-type saponins accounted for 36-75% of total saponins and contributed mostly to the difference in the total saponin content of each part.

KW - Different part

KW - Ginsenoside

KW - Ocotillol saponin

KW - Panax vietnamensis

KW - Vietnamese ginseng

UR - http://www.scopus.com/inward/record.url?scp=84955477537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955477537&partnerID=8YFLogxK

M3 - Article

VL - 63

SP - 950

EP - 954

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 11

ER -